Sprouty 2 Antibody - #DF14109

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Product: Sprouty 2 Antibody
Catalog: DF14109
Description: Rabbit polyclonal antibody to Sprouty 2
Application: IF/ICC
Reactivity: Human, Mouse
Mol.Wt.: 40kD; 35kD(Calculated).
Uniprot: O43597

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
Sprouty 2 Antibody detects endogenous levels of total Sprouty 2.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

hSPRY 2; hSPRY2; MGC23039; Protein sprouty homolog 2; Sprouty 2; Sprouty homolog 2 (Drosophila); Sprouty homolog 2; Sprouty2; Spry 2; Spry-2; SPRY2; SPY2_HUMAN;

Immunogens

Immunogen:

A synthesized peptide derived from Human Sprouty 2.

Uniprot:

O43597(SPY2_HUMAN) >>Visit HPA database.

Gene(ID):
SPRY2(10253)
Sequence:
MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHSSARAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKPGELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT

Research Backgrounds

Function:

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

PTMs:

Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).

Subcellular Location:

Cytoplasm>Cytoskeleton. Cell projection>Ruffle membrane.
Note: Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with RAF1. Part of a tripartite complex containing GAB1, METTL13 and SPRY2. Interacts with METTL13.

Family&Domains:

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Belongs to the sprouty family.

Research Fields

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

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