Hex Antibody - #DF14000

Product: Hex Antibody
Catalog: DF14000
Description: Rabbit polyclonal antibody to Hex
Application: ELISA(peptide)
Reactivity: Human, Mouse
Mol.Wt.: 30kD(Calculated).
Uniprot: Q03014

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
Hex Antibody detects endogenous levels of total Hex.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Hematopoietically expressed homeobox; Hematopoietically-expressed homeobox protein HHEX; HEX; HHEX; HHEX_HUMAN; HMPH; Homeobox hematopoietically expressed; Homeobox protein HEX; Homeobox protein PRH; HOX11L PEN; PRH; PRHX; Proline rich homeodomain containing transcription factor;

Immunogens

Immunogen:

A synthesized peptide derived from Human Hex.

Uniprot:

Q03014(HHEX_HUMAN) >>Visit HPA database.

Gene(ID):
HHEX(3087)
Expression:
Q03014 HHEX_HUMAN:

Liver and promyelocytic leukemia cell line HL-60.

Sequence:
MQYPHPGPAAGAVGVPLYAPTPLLQPAHPTPFYIEDILGRGPAAPTPAPTLPSPNSSFTSLVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKEELESLDSSCDQRQDLPSEQNKGASLDSSQCSPSPASQEDLESEISEDSDQEVDIEGDKSYFNAG

Research Backgrounds

Function:

Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Liver and promyelocytic leukemia cell line HL-60.

Subunit Structure:

Interacts with CD81; the interaction prevents nuclear translocation of HHEX.

Research Fields

· Human Diseases > Endocrine and metabolic diseases > Maturity onset diabetes of the young.

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

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