CRNKL1 Antibody | Affinity Biosciences

Product:	CRNKL1 Antibody
Catalog:	DF13949
Description:	Rabbit polyclonal antibody to CRNKL1
Application:	ELISA(peptide)
Reactivity:	Human, Mouse, Rat
Mol.Wt.:	100kD; 100kD(Calculated).
Uniprot:	Q9BZJ0

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Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

Size	Price	Inventory
100ul	$280	In stock
200ul	$350	In stock

Lead Time: Same day delivery

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Related Downloads

MS Report

HPLC Report

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human,Mouse,Rat

Clonality:

Polyclonal

Specificity:

CRNKL1 Antibody detects endogenous levels of total CRNKL1.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

1200013P10Rik; 5730590A01Rik; C80326; CLF; Clf1; CRN; Crn crooked neck like 1 (Drosophila); Crnkl1; CRNL1_HUMAN; Crooked neck homolog; Crooked neck like protein 1; Crooked neck pre mRNA splicing factor 1; Crooked neck-like protein 1; hCrn; MGC55327; MGC93283; MSTP021; SYF3; SYF3 pre mRNA splicing factor;

Immunogens

Immunogen:

A synthesized peptide derived from Human CRNKL1.

Uniprot:

Q9BZJ0(CRNL1_HUMAN) >>Visit HPA database.

Gene(ID):

CRNKL1(51340)

Expression:

Q9BZJ0 CRNL1_HUMAN:

Widely expressed (PubMed:11342225). Highly expressed in testis (PubMed:12084575). Not detected in brain and lung (PubMed:12084575).

Sequence:

Q9BZJ0 CRNL1_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MTATVENLTFQKDTLGNAVDKNTSRLELRSYSLAGRHGSTEPLVLAWSSQFRRLTWGCALDALHRSPCVAASQHGVTHLIRSSRTPHSTRCRKEDAQPGHHGNGAASVTAQARGQRSVLQVPLPVPRSCLFSESFVVSVSSQSRFLASVPGTGVQRSTAADMAASTAAGKQRIPKVAKVKNKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRTVISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWDRAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVDRARTIYERFVLVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQYEEEVKANPHNYDAWFDYLRLVESDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWINYALYEELEAKDPERTRQVYQASLELIPHKKFTFAKMWILYAQFEIRQKNLSLARRALGTSIGKCPKNKLFKVYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIDRARAIYELAISQPRLDMPEVLWKSYIDFEIEQEETERTRNLYRRLLQRTQHVKVWISFAQFELSSGKEGSLTKCRQIYEEANKTMRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPEKVKKRRKVQTDDGSDAGWEEYFDYIFPEDAANQPNLKLLAMAKLWKKQQQEKEDAEHHPDEDVDESES

Research Backgrounds

Q9BZJ0_CRNL1_HUMAN

Function:

Involved in pre-mRNA splicing process.

Subcellular Location:

Nucleus. Nucleus speckle.
Note: Colocalizes with core spliceosomal snRNP proteins (PubMed:12084575).

Tissue Specificity:

Widely expressed. Highly expressed in testis. Not detected in brain and lung.

Subunit Structure:

Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro containing CRNKL1, HPRP8BP and SNRPB2. Isoform 2 seems to be predominant in the spliceosome complex. Interacts with PPIL2 (via the PPIase cyclophilin-type domain); they may form a trimeric complex with HSP90.

Family&Domains:

Belongs to the crooked-neck family.

Research Fields

· Genetic Information Processing > Transcription > Spliceosome.

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CRNKL1 Antibody - #DF13949