TGF beta induced factor 2 Antibody - #DF13939

Product: TGF beta induced factor 2 Antibody
Catalog: DF13939
Description: Rabbit polyclonal antibody to TGIF2
Application: ELISA(peptide)
Reactivity: Human, Mouse, Rat
Mol.Wt.: 27kD; 26kD(Calculated).
Uniprot: Q9GZN2

View similar products>>

   Size Price Inventory
 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

For pricing and ordering contact:
Local distributors
Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
TGF beta induced factor 2 Antibody detects endogenous levels of total TGF beta induced factor 2.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

5' TG 3' interacting factor 2; 5''-TG-3''-interacting factor 2; Homeobox protein TGIF2; TGF (beta) induced transcription factor 2; TGF beta induced factor 2; TGF-beta-induced transcription factor 2; TGFB induced factor 2; TGFB-induced factor 2; Tgif2; TGIF2_HUMAN; Transforming growth factor beta induced factor 2;

Immunogens

Immunogen:

A synthesized peptide derived from Human TGIF2.

Uniprot:

Q9GZN2(TGIF2_HUMAN) >>Visit HPA database.

Gene(ID):
TGIF2(60436)
Expression:
Q9GZN2 TGIF2_HUMAN:

Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.

Sequence:
MSDSDLGEDEGLLSLAGKRKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPDMLRKDGKDPNQFTISRRGGKASDVALPRGSSPSVLAVSVPAPTNVLSLSVCSMPLHSGQGEKPAAPFPRGELESPKPLVTPGSTLTLLTRAEAGSPTGGLFNTPPPTPPEQDKEDFSSFQLLVEVALQRAAEMELQKQQDPSLPLLHTPIPLVSENPQ

Research Backgrounds

Function:

Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.

PTMs:

The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.

Subcellular Location:

Nucleus.
Note: Excluded from nucleoli.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.

Subunit Structure:

Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.

Family&Domains:

Belongs to the TALE/TGIF homeobox family.

Research Fields

· Environmental Information Processing > Signal transduction > TGF-beta signaling pathway.   (View pathway)

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.