Melatonin Receptor 1A Antibody - #DF13877

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Product: Melatonin Receptor 1A Antibody
Catalog: DF13877
Description: Rabbit polyclonal antibody to Melatonin Receptor 1A
Application: WB IHC IF/ICC
Cited expt.: WB
Reactivity: Human, Mouse, Rat
Mol.Wt.: 40kD; 39kD(Calculated).
Uniprot: P48039

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
Melatonin Receptor 1A Antibody detects endogenous levels of total Melatonin Receptor 1A.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Mel 1A R; MEL-1A-R; Mel1a melatonin receptor; Mel1a receptor; Melatonin receptor 1A; Melatonin receptor type 1A; MelR; MR; MT 1; MT1; MTNR 1A; MTNR1A; MTR1A_HUMAN;

Immunogens

Immunogen:

A synthesized peptide derived from Human Melatonin Receptor 1A.

Uniprot:

P48039(MTR1A_HUMAN) >>Visit HPA database.

Gene(ID):
MTNR1A(4543)
Expression:
P48039 MTR1A_HUMAN:

Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.

Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV

Research Backgrounds

Function:

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Subcellular Location:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.

Family&Domains:

Belongs to the G-protein coupled receptor 1 family.

Research Fields

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Organismal Systems > Environmental adaptation > Circadian entrainment.

References

1). Oligodendrocyte-astrocyte crosstalk in Parkinson's disease mediates neuronal ferroptosis via the FGF signaling pathway. NPJ Parkinson's disease, 2025 (PubMed: 40410211) [IF=8.7]

Application: WB    Species: Mouse    Sample:

Fig. 7: Oxidative phosphorylation and ferroptosis processes are activated in oligodendrocytes and astrocytes. A The results of the Western Blot show that the protein expression levels of Slc25a4, Ndufa4, and Atp6v0c, which are related to mitochondrial oxidative phosphorylation, are significantly increased in astrocytes and oligodendrocytes under PD conditions. Additionally, in PD astrocytes, there is a significant decrease in the expression of the Mt1 protein. B The results of the ELISA kit show that the Ca2+ content in astrocytes of PD mice is significantly increased. At the same time, the iron ion content in the SN of mice is significantly elevated, while the GSH content, total SOD activity, and MDA content are significantly decreased, indicating the presence of high levels of ROS and the activation of ferroptosis processes in the SN of PD mice.
2). Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways. Journal of pineal research, 2025 (PubMed: 40065592) [IF=8.3]

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