JunD Antibody - #AF6200
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF6200, RRID:AB_2835081.
Fold/Unfold
Activator protein 1; AP 1; AP1; Jun D; jun D proto oncogene; Jund; JunD FL isoform; JUND_HUMAN; Transcription factor jun D; Transcription factor jun-D;
Immunogens
- P17535 JUND_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
METPFYGDEALSGLGGGASGSGGSFASPGRLFPGAPPTAAAGSMMKKDALTLSLSEQVAAALKPAAAPPPTPLRADGAPSAAPPDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTSSQFLYPKVAASEEQEFAEGFVKALEDLHKQNQLGAGAAAAAAAAAAGGPSGTATGSAPPGELAPAAAAPEAPVYANLSSYAGGAGGAGGAATVAFAAEPVPFPPPPPPGALGPPRLAALKDEPQTVPDVPSFGESPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P17535 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S27 | Phosphorylation | Uniprot | |
| T38 | Phosphorylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| T71 | Phosphorylation | Uniprot | |
| S90 | Phosphorylation | P45983 (MAPK8) | Uniprot |
| K97 | Ubiquitination | Uniprot | |
| S100 | Phosphorylation | P45983 (MAPK8) , P27361 (MAPK3) , P28482 (MAPK1) | Uniprot |
| T117 | Phosphorylation | P45983 (MAPK8) | Uniprot |
| K127 | Ubiquitination | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K240 | Sumoylation | Uniprot | |
| T245 | Phosphorylation | Uniprot | |
| S251 | Phosphorylation | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| T265 | Phosphorylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| T308 | Phosphorylation | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| T313 | Phosphorylation | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| K327 | Ubiquitination | Uniprot |
Research Backgrounds
Transcription factor binding AP-1 sites.
Phosphorylated by MAP kinases MAPK8 and MAPK10; phosphorylation is inhibited in the presence of MEN1.
Nucleus.
Binds DNA as a dimer (By similarity). Interacts (via MBM motif) with MEN1; this interaction represses transcriptional activation. Interacts with MAPK10; this interaction is inhibited in the presence of MEN1.
Belongs to the bZIP family. Jun subfamily.
Research Fields
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > IL-17 signaling pathway. (View pathway)
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