Claudin 6 Antibody | Affinity Biosciences

IF/ICC

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Product:	Claudin 6 Antibody
Catalog:	AF6972
Description:	Rabbit polyclonal antibody to Claudin 6
Application:	IF/ICC
Reactivity:	Human, Mouse, Rat
Mol.Wt.:	23kD(Calculated).
Uniprot:	P56747
RRID:	AB_2847762

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Blocking Peptides

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

Size	Price	Inventory
100ul	$280	In stock
200ul	$350	In stock

Lead Time: Same day delivery

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Local distributors

Related Downloads

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human,Mouse,Rat

Clonality:

Polyclonal

Specificity:

Claudin 6 Antibody detects endogenous levels of total Claudin 6.

RRID:

AB_2847762
Cite Format: Affinity Biosciences Cat# AF6972, RRID:AB_2847762.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

Claudin-6; Claudin6; CLD6_HUMAN; CLDN 6; CLDN6; OTTHUMP00000159248; Skullin 2; Skullin; UNQ757/PRO1488;

Immunogens

Immunogen:

A synthesized peptide derived from human Claudin 6.

Uniprot:

P56747(CLD6_HUMAN) >>Visit HPA database.

Gene(ID):

CLDN6(9074)

Expression:

P56747 CLD6_HUMAN:

Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.

Sequence:

P56747 CLD6_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV

PTMs - P56747 As Substrate

P56747

Site	PTM Type	Source
Y200	Phosphorylation	Uniprot
S201	Phosphorylation	Uniprot
T202	Phosphorylation	Uniprot
S203	Phosphorylation	Uniprot
S208	Phosphorylation	Uniprot
S212	Phosphorylation	Uniprot
Y214	Phosphorylation	Uniprot
T216	Phosphorylation	Uniprot
K217	Ubiquitination	Uniprot
Y219	Phosphorylation	Uniprot

Research Backgrounds

P56747_CLD6_HUMAN

Function:

Plays a major role in tight junction-specific obliteration of the intercellular space.

(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.

Subcellular Location:

Cell junction>Tight junction. Cell membrane>Multi-pass membrane protein.

Tissue Specificity:

Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.

Subunit Structure:

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with CLDN1, CD81 and OCLN.

Family&Domains:

Belongs to the claudin family.

Research Fields

· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)

· Human Diseases > Infectious diseases: Viral > Hepatitis C.

· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)

Restrictive clause

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.

Claudin 6 Antibody - #AF6972