Product: SNAP23 Antibody
Catalog: AF6788
Description: Rabbit polyclonal antibody to SNAP23
Application: ELISA(peptide)
Reactivity: Human, Mouse, Rat
Mol.Wt.: 23kD(Calculated).
Uniprot: O00161
RRID: AB_2847511

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Product Info

Source:
Rabbit
Application:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
SNAP23 Antibody detects endogenous levels of total SNAP23.
RRID:
AB_2847511
Cite Format: Affinity Biosciences Cat# AF6788, RRID:AB_2847511.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

HsT17016; LS-B8340; SNAP 23; SNAP-23; SNAP23; SNAP23A; SNAP23B; SNP23_HUMAN; Synaptosomal associated protein 23; Synaptosomal associated protein 23kDa; Synaptosomal associated protein; Synaptosomal-associated protein 23; Vesicle membrane fusion protein SNAP 23; Vesicle membrane fusion protein SNAP23; Vesicle-membrane fusion protein SNAP-23;

Immunogens

Immunogen:

A synthesized peptide derived from human SNAP23.

Uniprot:
Gene(ID):
Expression:
O00161 SNP23_HUMAN:

Ubiquitous. Highest levels where found in placenta.

Sequence:
MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS

PTMs - O00161 As Substrate

Site PTM Type Enzyme
M1 Acetylation
S5 Phosphorylation
S6 Phosphorylation
T17 Phosphorylation
S20 Phosphorylation
S23 Phosphorylation P17252 (PRKCA)
T24 Phosphorylation P17252 (PRKCA)
S34 Phosphorylation
K40 Ubiquitination
K49 Ubiquitination
K64 Ubiquitination
K71 Ubiquitination
T72 Phosphorylation
K91 Ubiquitination
S95 Phosphorylation P14618 (PKM)
K97 Ubiquitination
Y99 Phosphorylation
K100 Ubiquitination
T102 Phosphorylation
S110 Phosphorylation
C112 S-Nitrosylation
K117 Ubiquitination
S136 Phosphorylation
Y139 Phosphorylation
K141 Ubiquitination
T144 Phosphorylation
T157 Phosphorylation
S161 Phosphorylation P17252 (PRKCA)
K185 Ubiquitination
K190 Ubiquitination

Research Backgrounds

Function:

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

Subcellular Location:

Cell membrane>Peripheral membrane protein. Cell membrane>Lipid-anchor. Cell junction>Synapse>Synaptosome.
Note: Mainly localized to the plasma membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitous. Highest levels where found in placenta.

Subunit Structure:

Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3. Found in a complex with VAMP8 and STX1A. Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (By similarity). Interacts with STX12 (By similarity). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats).

Family&Domains:

Belongs to the SNAP-25 family.

Research Fields

· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.

· Organismal Systems > Immune system > Platelet activation.   (View pathway)

Restrictive clause

 

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For Research Use Only.
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