SLC31A1 / CTR1 Antibody - #AF6773

Product: SLC31A1 / CTR1 Antibody
Catalog: AF6773
Description: Rabbit polyclonal antibody to SLC31A1 / CTR1
Application: ELISA(peptide)
Reactivity: Human, Mouse, Rat
Mol.Wt.: 21kD(Calculated).
Uniprot: O15431
RRID: AB_2847496

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
SLC31A1 / CTR1 Antibody detects endogenous levels of total SLC31A1 / CTR1.
RRID:
AB_2847496
Cite Format: Affinity Biosciences Cat# AF6773, RRID:AB_2847496.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Copper transport 1 homolog; Copper transporter 1; COPT1; COPT1_HUMAN; CTR1; hCTR1; High affinity copper uptake protein 1; SLC31A1; solute carrier family 31 (copper tansporters) member 1; Solute carrier family 31 member 1;

Immunogens

Immunogen:

A synthesized peptide derived from human SLC31A1 / CTR1.

Uniprot:

O15431(COPT1_HUMAN) >>Visit HPA database.

Gene(ID):
SLC31A1(1317)
Sequence:
MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH

PTMs - O15431 As Substrate

Site PTM Type Enzyme
S4 Phosphorylation
S10 Phosphorylation
Y11 Phosphorylation
N15 N-Glycosylation
T27 O-Glycosylation
K96 Ubiquitination
S105 Phosphorylation
T114 Phosphorylation

Research Backgrounds

Function:

High-affinity, saturable copper transporter involved in dietary copper uptake.

PTMs:

O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain.

Subcellular Location:

Cell membrane>Multi-pass membrane protein.
Note: Localizes to the apical membrane in intestinal epithelial cells.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Homotrimer.

Family&Domains:

Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.

Research Fields

· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.

· Organismal Systems > Digestive system > Mineral absorption.

Restrictive clause

 

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For Research Use Only.
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