Phospho-Tryptophan Hydroxylase (Ser58) Antibody - #AF3714

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Product: Phospho-Tryptophan Hydroxylase (Ser58) Antibody
Catalog: AF3714
Description: Rabbit polyclonal antibody to Phospho-Tryptophan Hydroxylase (Ser58)
Application: IHC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 51kD(Calculated).
Uniprot: P17752
RRID: AB_2847028

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 100ul $350 In stock
 200ul $450 In stock

Lead Time: Same day delivery

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
Phospho-Tryptophan Hydroxylase (Ser58) Antibody detects endogenous levels of Tryptophan Hydroxylase only when phosphorylated at Ser58.
RRID:
AB_2847028
Cite Format: Affinity Biosciences Cat# AF3714, RRID:AB_2847028.
Conjugate:
Unconjugated.
Purification:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Indoleacetic acid 5 hydroxylase; L tryptophan hydroxylase; MGC119994; TPH 1; TPH; TPH1; TPH1_HUMAN; TPRH; TRPH; Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; Tryptophan 5 monooxygenase; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; Tryptophan hydroxylase 1;

Immunogens

Immunogen:

A synthesized peptide derived from human Tryptophan Hydroxylase around the phosphorylation site of Ser58.

Uniprot:

P17752(TPH1_HUMAN) >>Visit HPA database.

Gene(ID):
TPH1(7166)
Expression:
P17752 TPH1_HUMAN:

Isoform 2 seems to be less widely expressed than isoform 1.

Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI

PTMs - P17752 As Substrate

Site PTM Type Enzyme
K33 Acetylation
S58 Phosphorylation
T225 Phosphorylation
S228 Phosphorylation
S260 Phosphorylation
Y373 Phosphorylation
Y401 Phosphorylation
Y404 Phosphorylation

Research Backgrounds

Tissue Specificity:

Isoform 2 seems to be less widely expressed than isoform 1.

Subunit Structure:

Homotetramer.

Family&Domains:

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Research Fields

· Metabolism > Amino acid metabolism > Tryptophan metabolism.

· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > Serotonergic synapse.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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