Phospho-TrkC (Tyr516) Antibody - #AF3582
Product: | Phospho-TrkC (Tyr516) Antibody |
Catalog: | AF3582 |
Description: | Rabbit polyclonal antibody to Phospho-TrkC (Tyr516) |
Application: | ELISA(peptide) |
Reactivity: | Human, Mouse, Rat |
Mol.Wt.: | 94kD(Calculated). |
Uniprot: | Q16288 |
RRID: | AB_2846896 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF3582, RRID:AB_2846896.
Fold/Unfold
EC 2.7.10.1; ETS related protein neurotrophic receptor tyrosine kinase fusion; ETS related protein neurotrophic receptor tyrosine kinase fusion protein; ETV6 NTRK3 fusion; GP145 TrkC; gp145(trkC); GP145-TrkC; GP145TrkC; Neurotrophic tyrosine kinase receptor type 3; Neurotrophin 3 receptor; NT 3 growth factor receptor; NT 3 growth factor receptor precursor; NT 3 receptor; NT-3 growth factor receptor; Ntrk3; NTRK3_HUMAN; OTTHUMP00000192915; TRK C; Trk-C; TRKC; TrkC tyrosine kinase; Tyrosine kinase receptor C;
Immunogens
A synthesized peptide derived from human TrkC around the phosphorylation site of Tyr516.
Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
- Q16288 NTRK3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
PTMs - Q16288 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
Y131 | Phosphorylation | Uniprot | |
T220 | Phosphorylation | Uniprot | |
T386 | Phosphorylation | Uniprot | |
Y516 | Phosphorylation | Q16288 (NTRK3) | Uniprot |
Y558 | Phosphorylation | Uniprot | |
S701 | Phosphorylation | Uniprot | |
Y705 | Phosphorylation | Uniprot | |
Y709 | Phosphorylation | Uniprot | |
Y710 | Phosphorylation | Uniprot | |
Y800 | Phosphorylation | Uniprot |
Research Backgrounds
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Ligand-mediated auto-phosphorylation.
Membrane>Single-pass type I membrane protein.
Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts with PTPRS. Interacts with MAPK8IP3/JIP3 (By similarity).
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Research Fields
· Human Diseases > Cancers: Overview > Central carbon metabolism in cancer. (View pathway)
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
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