Phospho-Histone H1 (Thr17) Antibody - #AF3572
| Product: | Phospho-Histone H1 (Thr17) Antibody |
| Catalog: | AF3572 |
| Description: | Rabbit polyclonal antibody to Phospho-Histone H1 (Thr17) |
| Application: | ELISA(peptide) |
| Reactivity: | Human |
| Mol.Wt.: | 36kD(Calculated). |
| Uniprot: | Q8IZA3 |
| RRID: | AB_2846886 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF3572, RRID:AB_2846886.
Fold/Unfold
H1 histone family member O oocyte specific; H1FOO; H1FOO_HUMAN; Histone H1oo; Oocyte-specific histone H1; Oocyte-specific linker histone H1; osH1;
Immunogens
A synthesized peptide derived from human Histone H1 around the phosphorylation site of Thr17.
- Q8IZA3 H1FOO_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPGSVTSDISPSSTSTAGSSRSPESEKPGPSHGGVPPGGPSHSSLPVGRRHPPVLRMVLEALQAGEQRRGTSVAAIKLYILHKYPTVDVLRFKYLLKQALATGMRRGLLARPLNSKARGATGSFKLVPKHKKKIQPRKMAPATAPRRAGEAKGKGPKKPSEAKEDPPNVGKVKKAAKRPAKVQKPPPKPGAATEKARKQGGAAKDTRAQSGEARKVPPKPDKAMRAPSSAGGLSRKAKAKGSRSSQGDAEAYRKTKAESKSSKPTASKVKNGAASPTKKKVVAKAKAPKAGQGPNTKAAAPAKGSGSKVVPAHLSRKTEAPKGPRKAGLPIKASSSKVSSQRAEA
PTMs - Q8IZA3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T7 | Phosphorylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| R147 | Methylation | Uniprot | |
| K153 | Acetylation | Uniprot | |
| K155 | Acetylation | Uniprot | |
| K158 | Acetylation | Uniprot | |
| K205 | Methylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| Y253 | Phosphorylation | Uniprot |
Research Backgrounds
May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).
Cytoplasm. Nucleus. Chromosome.
Oocyte-specific.
Belongs to the histone H1/H5 family.
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