Phospho-SIRT6 (Ser338) Antibody - #AF3569
| Product: | Phospho-SIRT6 (Ser338) Antibody |
| Catalog: | AF3569 |
| Description: | Rabbit polyclonal antibody to Phospho-SIRT6 (Ser338) |
| Application: | IHC IF/ICC |
| Reactivity: | Human, Rat |
| Mol.Wt.: | 39kD(Calculated). |
| Uniprot: | Q8N6T7 |
| RRID: | AB_2846883 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF3569, RRID:AB_2846883.
Fold/Unfold
2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; Regulatory protein SIR2 homolog; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIR6_HUMAN; SIRT 6; SIRT6; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6;
Immunogens
A synthesized peptide derived from human SIRT6 around the phosphorylation site of Ser338.
- Q8N6T7 SIR6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
PTMs - Q8N6T7 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| T146 | Phosphorylation | Uniprot | |
| Y148 | Phosphorylation | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| T162 | Phosphorylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| T294 | Phosphorylation | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| T305 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| T337 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | P31749 (AKT1) | Uniprot |
Research Backgrounds
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Nucleus>Nucleoplasm.
Note: Predominantly nuclear. Associated with telomeric heterochromatin regions.
Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.
Belongs to the sirtuin family. Class IV subfamily.
Research Fields
· Human Diseases > Cancers: Overview > Central carbon metabolism in cancer. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.