Phospho-DARPP32 (Ser137) Antibody - #AF3519
| Product: | Phospho-DARPP32 (Ser137) Antibody |
| Catalog: | AF3519 |
| Description: | Rabbit polyclonal antibody to Phospho-DARPP32 (Ser137) |
| Application: | ELISA(peptide) |
| Reactivity: | Human, Mouse, Rat |
| Mol.Wt.: | 23kD(Calculated). |
| Uniprot: | Q9UD71 |
| RRID: | AB_2846833 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF3519, RRID:AB_2846833.
Fold/Unfold
DARPP 32; DARPP-32; Dopamine and cAMP regulated neuronal phosphoprotein 32; Dopamine and cAMP regulated neuronal phosphoprotein; Dopamine and cAMP regulated phosphoprotein; Dopamine and cAMP regulated phosphoprotein DARPP 32; Dopamine and cAMP regulated phosphoprotein DARPP32; Dopamine- and cAMP-regulated neuronal phosphoprotein; FLJ20940; IPPD; Neuronal phosphoprotein DARPP 32; PPP1R1B; PPR1B_HUMAN; Protein phosphatase 1 regulatory (inhibitor) subunit 1B; Protein phosphatase 1 regulatory inhibitor subunit 1B; Protein phosphatase 1 regulatory subunit 1B;
Immunogens
A synthesized peptide derived from human DARPP32 around the phosphorylation site of Ser137.
- Q9UD71 PPR1B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLEGPWERPPPLDESERDGGSEDQVEDPALSEPGEEPQRPSPSEPGT
PTMs - Q9UD71 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S12 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| T34 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S45 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| Y74 | Phosphorylation | Uniprot | |
| T75 | Phosphorylation | Q00535 (CDK5) | Uniprot |
| S78 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| Y116 | Phosphorylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| S172 | Phosphorylation | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| S188 | Phosphorylation | Uniprot |
Research Backgrounds
Inhibitor of protein-phosphatase 1.
Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.
Phosphorylation of Thr-34 is required for activity.
Cytoplasm.
Belongs to the protein phosphatase inhibitor 1 family.
Research Fields
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Human Diseases > Substance dependence > Cocaine addiction.
· Human Diseases > Substance dependence > Amphetamine addiction.
· Human Diseases > Substance dependence > Alcoholism.
· Organismal Systems > Nervous system > Dopaminergic synapse.
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