Phospho-FUNDC1 (Ser17) antibody - #AF0001
*The optimal dilutions should be determined by the end user.
Cite Format: Affinity Biosciences Cat# AF0001, RRID:AB_2846773.
FUN14 domain containing 1; FUN14 domain containing protein 1; FUN14 domain-containing protein 1; FUND1_HUMAN; fundc1;
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8IVP5 As Substrate
Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy.
Mitochondrion outer membrane>Multi-pass membrane protein.
Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.
The YXXL motif mediates the interaction with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.
Belongs to the FUN14 family.
Application: WB Species: Sheep Sample: kidney tissue
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