SEC61A Antibody - #DF13740
| Product: | SEC61A Antibody |
| Catalog: | DF13740 |
| Description: | Rabbit polyclonal antibody to SEC61A |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat, Monkey |
| Prediction: | Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 52kDa; 52kD(Calculated). |
| Uniprot: | P61619 |
| RRID: | AB_2846759 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13740, RRID:AB_2846759.
Fold/Unfold
chunp6898; fb62c11; HSEC61; protein transport protein SEC61 alpha subunit; protein transport protein Sec61 subunit alpha; Protein transport protein Sec61 subunit alpha isoform 1; S61A1_HUMAN; SEC 61; SEC 61A; Sec61 alpha 1; Sec61 alpha 1 subunit; Sec61 alpha 1 subunit (S. cerevisiae); Sec61 alpha-1; SEC61; Sec61 homolog; SEC61A1; sec61aa;
Immunogens
- P61619 S61A1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P61619 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K4 | Ubiquitination | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| K21 | Ubiquitination | Uniprot | |
| T75 | Phosphorylation | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| T86 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| T105 | Phosphorylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| R273 | Methylation | Uniprot | |
| Y276 | Phosphorylation | Uniprot | |
| Y344 | Phosphorylation | Uniprot | |
| S346 | Phosphorylation | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| T407 | Phosphorylation | Uniprot | |
| S408 | Phosphorylation | Uniprot |
Research Backgrounds
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis. Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Note: Localizes exclusively in granular structures in the endoplasmic reticulum (ER).
Expressed in proximal and distal tubules in kidney (at protein level).
The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63.
Belongs to the SecY/SEC61-alpha family.
Research Fields
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Genetic Information Processing > Folding, sorting and degradation > Protein export.
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Vibrio cholerae infection.
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