TCP1 beta Antibody - #DF13690

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Product: TCP1 beta Antibody
Catalog: DF13690
Description: Rabbit polyclonal antibody to TCP1 beta
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 57kDa; 57kD(Calculated).
Uniprot: P78371
RRID: AB_2846709

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500, WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
Clonality:
Polyclonal
Specificity:
TCP1 beta Antibody detects endogenous levels of total TCP1 beta.
RRID:
AB_2846709
Cite Format: Affinity Biosciences Cat# DF13690, RRID:AB_2846709.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

99D8.1; CCT 2; CCT beta; CCT-beta; CCT2; CCTB; Chaperonin containing t complex polypeptide 1 beta subunit; Chaperonin containing t complex polypeptide 1 subunit 2; Chaperonin containing TCP1 subunit 2; Chaperonin containing TCP1 subunit 2 (beta); CTP:phosphocholine cytidylyltransferase 2; Epididymis secretory sperm binding protein Li 100n; HEL S 100n; MGC142074; MGC142076; MGC94480; PRO1633; T complex protein 1 beta subunit; T complex protein 1 subunit beta; T-complex protein 1 subunit beta; TCP 1 beta; TCP-1-beta; TCPB_HUMAN;

Immunogens

Immunogen:
Uniprot:

P78371(TCPB_HUMAN) >>Visit HPA database.

Gene(ID):
CCT2(10576)
Sequence:
MASLSLAPVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMREGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
100
Rabbit
100
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P78371 As Substrate

Site PTM Type Enzyme
A2 Acetylation
S3 Phosphorylation
S5 Phosphorylation
K13 Acetylation
K13 Ubiquitination
T23 Phosphorylation
S28 Phosphorylation
K40 Ubiquitination
K46 Ubiquitination
K50 Ubiquitination
S54 Phosphorylation
S55 Phosphorylation
S60 Phosphorylation
K72 Ubiquitination
K82 Ubiquitination
S115 Phosphorylation
K119 Ubiquitination
K120 Ubiquitination
S143 Phosphorylation
S150 Phosphorylation
K154 Acetylation
K154 Ubiquitination
T165 Phosphorylation
T166 Phosphorylation
S168 Phosphorylation
S169 Phosphorylation
K170 Ubiquitination
K176 Ubiquitination
K181 Acetylation
K191 Acetylation
K191 Ubiquitination
S193 Phosphorylation
K203 Ubiquitination
K204 Ubiquitination
S212 Phosphorylation
Y213 Phosphorylation
K222 Ubiquitination
K223 Sumoylation
K223 Ubiquitination
K230 Ubiquitination
K236 Ubiquitination
T242 Phosphorylation
T246 Phosphorylation
K248 Acetylation
K248 Ubiquitination
K250 Ubiquitination
S254 Phosphorylation
S260 Phosphorylation P31749 (AKT1) , Q15418 (RPS6KA1) , P23443 (RPS6KB1)
T261 Phosphorylation
K263 Ubiquitination
K272 Acetylation
K272 Ubiquitination
K278 Ubiquitination
K284 Methylation
K284 Ubiquitination
Y297 Phosphorylation
K342 Ubiquitination
K347 Ubiquitination
T379 Phosphorylation
S389 Phosphorylation
K402 Ubiquitination
S413 Phosphorylation
R427 Methylation
T428 Phosphorylation
K431 Acetylation
K431 Ubiquitination
S438 Phosphorylation
Y439 Phosphorylation
K441 Acetylation
K441 Ubiquitination
T448 Phosphorylation
Y456 Phosphorylation
S458 Phosphorylation
S470 Phosphorylation
K500 Ubiquitination
K522 Ubiquitination
K527 Ubiquitination
C535 S-Nitrosylation

Research Backgrounds

Function:

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).

Subcellular Location:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with FLCN.

Family&Domains:

Belongs to the TCP-1 chaperonin family.

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