SLC1A5 Antibody - #DF13643
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| Product: | SLC1A5 Antibody |
| Catalog: | DF13643 |
| Description: | Rabbit polyclonal antibody to SLC1A5 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 50kD,70~100kD(Glycosylated); 57kD(Calculated). |
| Uniprot: | Q15758 |
| RRID: | AB_2846662 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13643, RRID:AB_2846662.
Fold/Unfold
;ASCT2; AAAT; AAAT_HUMAN; ATB(0); ATBO; Baboon M7 virus receptor; FLJ31068; M7V1; M7VS1; Neutral amino acid transporter B(0); R16; RD114/simian type D retrovirus receptor; RDR; RDRC; SLC1A5; Sodium dependent neutral amino acid transporter type 2; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 (neutral amino acid transporter), member 5; Solute carrier family 1 member 5;
Immunogens
- Q15758 AAAT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESVM
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15758 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| Y38 | Phosphorylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| N212 | N-Glycosylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| S493 | Phosphorylation | Uniprot | |
| T494 | Phosphorylation | Uniprot | |
| K502 | Ubiquitination | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| K522 | Sumoylation | Uniprot | |
| K522 | Ubiquitination | Uniprot | |
| Y524 | Phosphorylation | Uniprot | |
| R525 | Methylation | Uniprot | |
| T532 | Phosphorylation | Uniprot | |
| S535 | Phosphorylation | Uniprot | |
| K537 | Acetylation | Uniprot | |
| K537 | Ubiquitination | Uniprot | |
| S539 | Phosphorylation | Uniprot |
Research Backgrounds
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development.
(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.
(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.
Cell membrane>Multi-pass membrane protein. Melanosome.
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.
Homotrimer (Probable). Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization.
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
Research Fields
· Human Diseases > Cancers: Overview > Central carbon metabolism in cancer. (View pathway)
· Organismal Systems > Digestive system > Protein digestion and absorption.
References
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