KDM4C / GASC1 / JMJD2C Antibody - #DF13567

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Product: KDM4C / GASC1 / JMJD2C Antibody
Catalog: DF13567
Description: Rabbit polyclonal antibody to KDM4C / GASC1 / JMJD2C
Application: WB
Reactivity: Human, Mouse, Rat
Mol.Wt.: 119kDa, 200 kDa; 120kD(Calculated).
Uniprot: Q9H3R0
RRID: AB_2846586

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
KDM4C / GASC1 / JMJD2C Antibody detects endogenous levels of total KDM4C / GASC1 / JMJD2C.
RRID:
AB_2846586
Cite Format: Affinity Biosciences Cat# DF13567, RRID:AB_2846586.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

bA146B14.1; GASC 1 protein; GASC-1 protein; GASC1; Gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JmjC domain containing histone demethylation protein 3C; JmjC domain-containing histone demethylation protein 3C; JMJD2C; Jumonji domain containing 2C; Jumonji domain containing protein 2C; Jumonji domain-containing protein 2C; Kdm4c; KDM4C_HUMAN; Lysine (K) specific demethylase 4C; Lysine demethylase 4C; Lysine-specific demethylase 4C; TDRD14C; Tudor domain containing 14C;

Immunogens

Immunogen:
Uniprot:

Q9H3R0(KDM4C_HUMAN) >>Visit HPA database.

Gene(ID):
KDM4C(23081)
Expression:
Q9H3R0 KDM4C_HUMAN:

Overexpressed in several esophageal squamous cell carcinomas (ESCs).

Sequence:
MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGERKRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ

PTMs - Q9H3R0 As Substrate

Site PTM Type Enzyme
S8 Phosphorylation
K31 Ubiquitination
K39 Ubiquitination
K97 Ubiquitination
K107 Ubiquitination
Y197 Phosphorylation
S198 Phosphorylation
Y201 Phosphorylation
K243 Ubiquitination
T245 Phosphorylation
S248 Phosphorylation
S250 Phosphorylation
K254 Ubiquitination
K303 Ubiquitination
K306 Ubiquitination
K335 Ubiquitination
K338 Ubiquitination
T353 Phosphorylation
K357 Ubiquitination
S392 Phosphorylation
S429 Phosphorylation
S482 Phosphorylation
S570 Phosphorylation
S576 Phosphorylation
S582 Phosphorylation
K671 Ubiquitination
K772 Acetylation
K809 Ubiquitination
T903 Phosphorylation
T906 Phosphorylation
Y908 Phosphorylation
S916 Phosphorylation
K933 Ubiquitination
K946 Ubiquitination
K951 Ubiquitination
T985 Phosphorylation
K992 Ubiquitination
T1009 Phosphorylation
K1031 Sumoylation

Research Backgrounds

Function:

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Overexpressed in several esophageal squamous cell carcinomas (ESCs).

Family&Domains:

The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity).

Belongs to the JHDM3 histone demethylase family.

Restrictive clause

 

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