CLCA1 Antibody - #DF13501
| Product: | CLCA1 Antibody |
| Catalog: | DF13501 |
| Description: | Rabbit polyclonal antibody to CLCA1 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 100kDa; 100kD(Calculated). |
| Uniprot: | A8K7I4 |
| RRID: | AB_2846520 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13501, RRID:AB_2846520.
Fold/Unfold
CaCC; CaCC-1; CACC1; Calcium dependent chloride channel 1; Calcium-activated chloride channel family member 1; Calcium-activated chloride channel protein 1; Calcium-activated chloride channel regulator 1; Chloride channel calcium activated family member 1; Chloride channel regulator 1; CLCA family member 1 chloride channel regulator; CLCA1; CLCA1_HUMAN; CLCRG1; GOB5; hCaCC-1; hCLCA1;
Immunogens
Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
- A8K7I4 CLCA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAASGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIAKVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDLFIAIQAVDKVDLKSEISNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILKIMWKWIGELQLSIA
PTMs - A8K7I4 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y91 | Phosphorylation | Uniprot | |
| Y99 | Phosphorylation | Uniprot | |
| Y147 | Phosphorylation | Uniprot | |
| C187 | S-Nitrosylation | Uniprot | |
| K208 | Acetylation | Uniprot | |
| T216 | Phosphorylation | Uniprot | |
| Y219 | Phosphorylation | Uniprot | |
| C308 | S-Nitrosylation | Uniprot | |
| S571 | Phosphorylation | Uniprot | |
| S572 | Phosphorylation | Uniprot | |
| T578 | Phosphorylation | Uniprot | |
| T580 | Phosphorylation | Uniprot | |
| Y661 | Phosphorylation | Uniprot | |
| Y665 | Phosphorylation | Uniprot | |
| Y671 | Phosphorylation | Uniprot |
Research Backgrounds
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Glycosylated.
The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
Secreted>Extracellular space. Cell membrane>Peripheral membrane protein>Extracellular side.
Note: Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.
Belongs to the CLCR family.
Research Fields
· Organismal Systems > Endocrine system > Renin secretion.
· Organismal Systems > Digestive system > Pancreatic secretion.
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