MAFK Antibody - #DF13483
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| Product: | MAFK Antibody |
| Catalog: | DF13483 |
| Description: | Rabbit polyclonal antibody to MAFK |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Dog, Chicken |
| Mol.Wt.: | 17kDa; 18kD(Calculated). |
| Uniprot: | O60675 |
| RRID: | AB_2846502 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13483, RRID:AB_2846502.
Fold/Unfold
Erythroid transcription factor NF E2 p18 subunit; Erythroid transcription factor NF-E2 p18 subunit; FLJ32205; MAFK; MAFK_HUMAN; MGC71717; Nfe2u; P18; Transcription factor MafK; V maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian);
Immunogens
- O60675 MAFK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVAPSKVATTSVITIVKSTELSSTSVPFSAAS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O60675 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S25 | Phosphorylation | Uniprot | |
| K46 | Sumoylation | Uniprot | |
| K46 | Ubiquitination | Uniprot | |
| K71 | Acetylation | Uniprot | |
| T74 | Phosphorylation | Uniprot | |
| K76 | Sumoylation | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K110 | Sumoylation | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| Y111 | Phosphorylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| T133 | Phosphorylation | Uniprot | |
| T134 | O-Glycosylation | Uniprot | |
| T134 | Phosphorylation | Uniprot | |
| S153 | O-Glycosylation | Uniprot |
Research Backgrounds
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.
Nucleus.
Homodimer or heterodimer. It can form high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3.
Belongs to the bZIP family. Maf subfamily.
References
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