Product: PERP Antibody
Catalog: DF13468
Description: Rabbit polyclonal antibody to PERP
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Horse, Rabbit, Dog
Mol.Wt.: 21kDa; 21kD(Calculated).
Uniprot: Q96FX8
RRID: AB_2846487

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Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(100%), Horse(80%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
PERP Antibody detects endogenous levels of total PERP.
RRID:
AB_2846487
Cite Format: Affinity Biosciences Cat# DF13468, RRID:AB_2846487.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

1110017A08Rik; dJ496H19.1; KCP 1; KCP-1; KCP1; Keratinocyte associated protein 1; Keratinocyte-associated protein 1; Keratinocytes associated protein 1; KRTCAP 1; KRTCAP1; p53 apoptosis effector related to PMP 22; p53 apoptosis effector related to PMP-22; p53 apoptosis effector related to PMP22; P53 induced protein PIGPC1; P53-induced protein PIGPC1; Perp; PERP TP53 apoptosis effector; PERP_HUMAN; PIGPC 1; PIGPC1; RP3 496H19.1; THW; TP53 apoptosis effector; Transmembrane protein THW;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q96FX8 PERP_HUMAN:

Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts.

Sequence:
MIRCGLACERCRWILPLLLLSAIAFDIIALAGRGWLQSSDHGQTSSLWWKCSQEGGGSGSYEEGCQSLMEYAWGRAAAAMLFCGFIILVICFILSFFALCGPQMLVFLRVIGGLLALAAVFQIISLVIYPVKYTQTFTLHANPAVTYIYNWAYGFGWAATIILIGCAFFFCCLPNYEDDLLGNAKPRYFYTSA

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Dog
100
Rabbit
100
Horse
80
Bovine
71
Sheep
71
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96FX8 As Substrate

Site PTM Type Enzyme
S46 Phosphorylation

Research Backgrounds

Function:

Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).

Subcellular Location:

Cell junction>Desmosome. Cell membrane>Multi-pass membrane protein.
Note: Associated with desmosomes.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts.

Family&Domains:

Belongs to the TMEM47 family.

Research Fields

· Cellular Processes > Cell growth and death > p53 signaling pathway.   (View pathway)

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For Research Use Only.
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