Natriuretic Peptide Receptor C Antibody

WB
IF/ICC

1/2

Western blot analysis of extracts from HL-60, using Natriuretic Peptide Receptor C Antibody.

Product:	Natriuretic Peptide Receptor C Antibody
Catalog:	DF13434
Description:	Rabbit polyclonal antibody to Natriuretic Peptide Receptor C
Application:	WB IF/ICC
Reactivity:	Human, Mouse, Rat
Prediction:	Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.:	59kDa; 60kD(Calculated).
Uniprot:	P17342
RRID:	AB_2846453

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Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

Size	Price	Inventory
100ul	$280	In stock
200ul	$350	In stock

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Related Downloads

MS Report

HPLC Report

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

IF/ICC 1:100-1:500, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human,Mouse,Rat

Prediction:

Pig(88%), Bovine(88%), Horse(100%), Sheep(88%), Rabbit(100%), Dog(100%)

Clonality:

Polyclonal

Specificity:

Natriuretic Peptide Receptor C Antibody detects endogenous levels of total Natriuretic Peptide Receptor C.

RRID:

AB_2846453
Cite Format: Affinity Biosciences Cat# DF13434, RRID:AB_2846453.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

ANP C; ANP-C; ANPC; ANPR-C; ANPRC; ANPRC_HUMAN; Atrial natriuretic peptide C type receptor; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor 3; Atrial natriuretic peptide receptor type C; Atrionatriuretic peptide receptor C; C5orf23; FLJ14054; GUCY2B; MGC22189; Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); Natriuretic peptide receptor C/guanylate cyclase C; NPR 3; NPR C; NPR-C; Npr3; NPRC;

Immunogens

Immunogen:

Uniprot:

P17342(ANPRC_HUMAN) >>Visit HPA database.

Gene(ID):

NPR3(4883)

Sequence:

P17342 ANPRC_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQEREALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDENRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRTQQEESNLGKHRELREDSIRSHFSVA

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species

Results

Score

Horse

100

Dog

100

Rabbit

100

Pig

Bovine

Sheep

Xenopus

Zebrafish

Chicken

Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P17342 As Substrate

P17342

Site	PTM Type	Source
N86	N-Glycosylation	Uniprot
S148	Phosphorylation	Uniprot
S156	Phosphorylation	Uniprot
N293	N-Glycosylation	Uniprot
Y316	Phosphorylation	Uniprot
N394	N-Glycosylation	Uniprot
Y502	Phosphorylation	Uniprot
K525	Ubiquitination	Uniprot
S533	Phosphorylation	Uniprot

Research Backgrounds

P17342_ANPRC_HUMAN

Function:

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.

Subcellular Location:

Membrane>Single-pass type I membrane protein.

Subunit Structure:

Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2. Interacts with OSTN (By similarity).

Family&Domains:

Belongs to the ANF receptor family.

Restrictive clause

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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Natriuretic Peptide Receptor C Antibody - #DF13434