SV2A Antibody - #DF13377
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13377, RRID:AB_2846396.
Fold/Unfold
KIAA0736; OTTHUMP00000014065; SV2; Sv2a; SV2A_HUMAN; Synaptic vesicle glycoprotein 2; Synaptic vesicle glycoprotein 2A; Synaptic vesicle protein 2a;
Immunogens
- Q7L0J3 SV2A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPAPSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q7L0J3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K32 | Ubiquitination | Uniprot | |
| Y41 | Phosphorylation | Uniprot | |
| S42 | Phosphorylation | Q6IQ55 (TTBK2) | Uniprot |
| S45 | Phosphorylation | Q6IQ55 (TTBK2) | Uniprot |
| S47 | Phosphorylation | Q6IQ55 (TTBK2) | Uniprot |
| S62 | Phosphorylation | Uniprot | |
| Y65 | Phosphorylation | Uniprot | |
| Y66 | Phosphorylation | Uniprot | |
| T71 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Q6IQ55 (TTBK2) | Uniprot |
| S81 | Phosphorylation | Q6IQ55 (TTBK2) | Uniprot |
| T84 | Phosphorylation | Q6IQ55 (TTBK2) | Uniprot |
| Y94 | Phosphorylation | Uniprot | |
| Y98 | Phosphorylation | Uniprot | |
| R123 | Methylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| Y212 | Phosphorylation | Uniprot | |
| K366 | Ubiquitination | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| T395 | Phosphorylation | Uniprot | |
| S411 | Phosphorylation | Uniprot | |
| Y480 | Phosphorylation | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| K515 | Ubiquitination | Uniprot |
Research Backgrounds
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.
Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.
N-glycosylated.
Cell junction>Synapse>Presynapse. Cytoplasmic vesicle>Secretory vesicle>Synaptic vesicle membrane>Multi-pass membrane protein.
Note: Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals.
Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 (By similarity).
(Microbial infection) Interacts with C.botulinum neurotoxin type A2 (BoNT/A, botA). Interaction is improved by glycosylation of SV2.
Belongs to the major facilitator superfamily.
Research Fields
· Environmental Information Processing > Signaling molecules and interaction > ECM-receptor interaction. (View pathway)
References
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