CNGA2 Antibody - #DF13311
| Product: | CNGA2 Antibody |
| Catalog: | DF13311 |
| Description: | Rabbit polyclonal antibody to CNGA2 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 76kDa; 76kD(Calculated). |
| Uniprot: | Q16280 |
| RRID: | AB_2846330 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13311, RRID:AB_2846330.
Fold/Unfold
CNCA; CNCA1; CNCG2; CNG 2; CNG channel alpha 2; CNG channel alpha-2; CNG-2; CNG2; CNGA 2; Cnga2; CNGA2_HUMAN; Cyclic nucleotide gated cation channel 2; Cyclic nucleotide gated channel alpha 2; Cyclic nucleotide gated olfactory channel; Cyclic nucleotide-gated cation channel 2; Cyclic nucleotide-gated channel alpha-2; Cyclic nucleotide-gated olfactory channel; FLJ46312; OCNC1; OCNCa; OCNCALPHA;
Immunogens
A synthesized peptide derived from human CNGA2, corresponding to a region within C-terminal amino acids.
- Q16280 CNGA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAAADEP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16280 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y395 | Phosphorylation | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| Y492 | Phosphorylation | Uniprot | |
| S546 | Phosphorylation | Uniprot | |
| S552 | Phosphorylation | Uniprot | |
| Y563 | Phosphorylation | Uniprot | |
| T634 | Phosphorylation | Uniprot |
Research Backgrounds
Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
Membrane>Multi-pass membrane protein.
Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity).
The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
Research Fields
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Organismal Systems > Sensory system > Olfactory transduction.
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