MTUS1 Antibody - #DF13161

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Product: MTUS1 Antibody
Catalog: DF13161
Description: Rabbit polyclonal antibody to MTUS1
Application: WB IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 114 kDa; 141kD(Calculated).
Uniprot: Q9ULD2
RRID: AB_2846121

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
MTUS1 Antibody detects endogenous levels of total MTUS1.
RRID:
AB_2846121
Cite Format: Affinity Biosciences Cat# DF13161, RRID:AB_2846121.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

AGTR2-interacting protein; Angiotensin II type 2 receptor interacting protein; AT2 receptor interacting protein; AT2 receptor-binding protein; AT2R binding protein; ATBP; ATIP; ATIP1; DKFZp586D1519; DKFZp686F20243; Erythroid differentiation related; FLJ14295; GK 1; GK1; KIAA1288; Microtubule associated tumor suppressor 1; Mitochondrial tumor suppressor 1; Mitochondrial tumor suppressor gene 1; MP 44; MP44; MTSG 1; MTSG1; MTUS 1; Transcription factor MTSG1;

Immunogens

Immunogen:
Uniprot:

Q9ULD2(MTUS1_HUMAN) >>Visit HPA database.

Gene(ID):
MTUS1(57509)
Expression:
Q9ULD2 MTUS1_HUMAN:

Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain.

Sequence:
MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSVNWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFISKQVLDMHKDSICQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQTFDMTVDKVNCTFISHHAIGKSQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHARETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGKVTSEYTDGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMGQNLRETVSYCLIDDECPLMVPAFDKSEAQVLNPEHKVTETEDTQMVSKGKDLGTQNHTSELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEKCKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFKNVKAKVMSRAVLQPKDAALSKVTPRPQQTSASSPSSVNSRQQTVLSRTPRSDLNADKKAEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSACETGSVSALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELKQEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLRQIAAPKAKVGPPVSCLRRNSDNRNPSADRAVSPQRIRRVSSSGKPTSLKTAQSSWVNLPRPLPKSKASLKSPALRRTGSTPSIASTHSELSTYSNNSGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR

PTMs - Q9ULD2 As Substrate

Site PTM Type Enzyme
S6 Phosphorylation
S85 Phosphorylation
T171 Phosphorylation
K180 Methylation
S183 Phosphorylation
T186 Phosphorylation
S197 Phosphorylation
S279 Phosphorylation
S360 Phosphorylation
S399 Phosphorylation
S408 Phosphorylation
T412 Phosphorylation
T430 Phosphorylation
S443 Phosphorylation
K462 Ubiquitination
S478 Phosphorylation
T488 Phosphorylation
S528 Phosphorylation
S541 Phosphorylation
T556 Phosphorylation
T584 Phosphorylation
T591 Phosphorylation
S629 Phosphorylation
T654 Phosphorylation
Y655 Phosphorylation
S663 Phosphorylation
S694 Phosphorylation
T704 Phosphorylation
T706 Phosphorylation
S707 Phosphorylation
S712 Phosphorylation
S716 Phosphorylation
S740 Phosphorylation
S752 Phosphorylation
S760 Phosphorylation
S761 Phosphorylation
S762 Phosphorylation
T766 Phosphorylation
S767 Phosphorylation
K786 Methylation
K790 Methylation
S791 Phosphorylation
S799 Phosphorylation
T800 Phosphorylation
Y825 Phosphorylation
T858 Phosphorylation
S878 Phosphorylation
S916 Phosphorylation
K955 Ubiquitination
S958 Phosphorylation
K1081 Acetylation
K1082 Ubiquitination
K1091 Acetylation
K1091 Ubiquitination
S1199 Phosphorylation
S1203 Phosphorylation
T1204 Phosphorylation
S1212 Phosphorylation
S1224 Phosphorylation
S1241 Phosphorylation
S1245 Phosphorylation
T1247 Phosphorylation
S1255 Phosphorylation
S1259 Phosphorylation
S1264 Phosphorylation
S1266 Phosphorylation
S1268 Phosphorylation

Research Backgrounds

Function:

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.

Subcellular Location:

Mitochondrion. Golgi apparatus. Cell membrane. Nucleus.
Note: In neurons, translocates into the nucleus after treatment with angiotensin-II.

Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Spindle.
Note: Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain.

Subunit Structure:

Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with microtubules.

Family&Domains:

Belongs to the MTUS1 family.

References

1). Angiotensin II Type 2 Receptor Agonist Reduces the Inflammation and Pain Hypersensitivity in Mice with Joint Inflammatory Pain. International Immunopharmacology, 2022 (PubMed: 35724606) [IF=5.6]

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