MDH2 Antibody - #DF13140
| Product: | MDH2 Antibody |
| Catalog: | DF13140 |
| Description: | Rabbit polyclonal antibody to MDH2 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 33 kDa; 36kD(Calculated). |
| Uniprot: | P40926 |
| RRID: | AB_2846100 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13140, RRID:AB_2846100.
Fold/Unfold
M MDH; Malate dehydrogenase 2, NAD (mitochondrial); Malate dehydrogenase; Malate dehydrogenase, mitochondrial; MDH; mdh2; MDHM_HUMAN; MGC:3559; mitochondrial; Mitochondrial malate dehydrogenase 2, NAD; Mor 1; MOR1;
Immunogens
- P40926 MDHM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P40926 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S18 | Phosphorylation | Uniprot | |
| S33 | Phosphorylation | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| Y56 | Phosphorylation | Uniprot | |
| T61 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| K74 | Acetylation | Uniprot | |
| K74 | Ubiquitination | Uniprot | |
| K78 | Acetylation | Uniprot | |
| K78 | Ubiquitination | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| K91 | Acetylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K156 | Acetylation | Uniprot | |
| K157 | Acetylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| Y161 | Phosphorylation | Uniprot | |
| K165 | Acetylation | Uniprot | |
| T170 | Phosphorylation | Uniprot | |
| T171 | Phosphorylation | Uniprot | |
| K185 | Acetylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K203 | Acetylation | Uniprot | |
| K203 | Ubiquitination | Uniprot | |
| T204 | Phosphorylation | Uniprot | |
| C212 | S-Nitrosylation | Uniprot | |
| T213 | Phosphorylation | Uniprot | |
| K215 | Acetylation | Uniprot | |
| T224 | Phosphorylation | Uniprot | |
| T227 | Phosphorylation | Uniprot | |
| T235 | Phosphorylation | Uniprot | |
| K239 | Acetylation | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| T248 | Phosphorylation | Uniprot | |
| Y253 | Phosphorylation | Uniprot | |
| R257 | Methylation | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| S276 | Phosphorylation | Uniprot | |
| S280 | Phosphorylation | Uniprot | |
| T283 | Phosphorylation | Uniprot | |
| C285 | S-Nitrosylation | Uniprot | |
| T286 | Phosphorylation | Uniprot | |
| Y287 | Phosphorylation | Uniprot | |
| K296 | Acetylation | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| K297 | Acetylation | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| K301 | Acetylation | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K307 | Acetylation | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| K314 | Acetylation | Uniprot | |
| K314 | Ubiquitination | Uniprot | |
| S317 | Phosphorylation | Uniprot | |
| K324 | Acetylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| K328 | Acetylation | Uniprot | |
| K329 | Acetylation | Uniprot | |
| K335 | Acetylation | Uniprot | |
| K335 | Ubiquitination | Uniprot | |
| T336 | Phosphorylation | Uniprot |
Research Backgrounds
Acetylation is enhanced by up to 67% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with the appearance of tri- and tetraacetylations. Glucose also increases acetylation by about 60%.
Mitochondrion matrix.
Homodimer.
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Research Fields
· Metabolism > Carbohydrate metabolism > Citrate cycle (TCA cycle).
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Carbohydrate metabolism > Pyruvate metabolism.
· Metabolism > Carbohydrate metabolism > Glyoxylate and dicarboxylate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
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