GALNT4 Antibody - #DF13031
| Product: | GALNT4 Antibody |
| Catalog: | DF13031 |
| Description: | Rabbit polyclonal antibody to GALNT4 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine |
| Mol.Wt.: | 67 kDa; 67kD(Calculated). |
| Uniprot: | Q8N4A0 |
| RRID: | AB_2845992 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13031, RRID:AB_2845992.
Fold/Unfold
EC 2.4.1.41; GALNAC T4; GalNAc transferase 4; GalNAc-T4; GalNAcT4; GALNT4; GALT4_HUMAN; N-acetylgalactosaminyltransferase 4 (GalNAc-T4); Polypeptide GalNAc transferase 4; Polypeptide N-acetylgalactosaminyltransferase 4; pp GaNTase 4; pp-GaNTase 4; Protein UDP acetylgalactosaminyltransferase 4; Protein-UDP acetylgalactosaminyltransferase 4; UDP GalNAc:polypeptide N-acetylgalactosaminyltransferase 4; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4; UDP-N-acetyl-alpha-D-galactosamine:polypeptide;
Immunogens
- Q8N4A0 GALT4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAVRWTWAGKSCLLLAFLTVAYIFVELLVSTFHASAGAGRARELGSRRLSDLQKNTEDLSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERYAINIYLSDRISLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLSDRVYLKTQLETYISNLDRVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNSGWLEPLLERIGRDETAVVCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRISRIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEHFYNRNPPARKEAYGDISERKLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRSRGISSECLDYNSPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPEQKNYVGMQNCPKDGFPVPANIIWHFKEDGTIFHPHSGLCLSAYRTPEGRPDVQMRTCDALDKNQIWSFEK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8N4A0 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S50 | Phosphorylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| T154 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| S177 | Phosphorylation | Uniprot | |
| Y181 | Phosphorylation | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| T308 | Phosphorylation | Uniprot | |
| Y390 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot |
Research Backgrounds
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.
Golgi apparatus membrane>Single-pass type II membrane protein.
Ubiquitous. Highly expressed in mucous cells.
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates.
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Research Fields
· Metabolism > Glycan biosynthesis and metabolism > Mucin type O-glycan biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
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