EPCR Antibody - #DF12980
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| Product: | EPCR Antibody |
| Catalog: | DF12980 |
| Description: | Rabbit polyclonal antibody to EPCR |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Mol.Wt.: | 49 kDa; 27kD(Calculated). |
| Uniprot: | Q9UNN8 |
| RRID: | AB_2845941 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12980, RRID:AB_2845941.
Fold/Unfold
Activated protein C receptor; APC receptor; APCR; bA42O4.2; CCCA; CCD41; CD201; CD201 antigen; cell cycle, centrosome-associated protein; Cell cycle, centrosome-associated protein; centrocyclin; Endothelial cell protein C receptor; Endothelial protein C receptor; EPCR; EPCR_HUMAN; MGC23024; PROCR; Protein C receptor, endothelial;
Immunogens
Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
- Q9UNN8 EPCR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC
PTMs - Q9UNN8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N47 | N-Glycosylation | Uniprot | |
| N136 | N-Glycosylation | Uniprot | |
| N172 | N-Glycosylation | Uniprot | |
| S195 | Phosphorylation | Uniprot | |
| T204 | Phosphorylation | Uniprot |
Research Backgrounds
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
N-glycosylated.
A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.
Membrane>Single-pass type I membrane protein.
Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
Research Fields
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
References
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