DCP1B Antibody - #DF12929

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Product: DCP1B Antibody
Catalog: DF12929
Description: Rabbit polyclonal antibody to DCP1B
Application: WB
Reactivity: Human, Mouse, Rat
Prediction: Horse
Mol.Wt.: 68 kDa; 68kD(Calculated).
Uniprot: Q8IZD4
RRID: AB_2845890

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Horse(83%)
Clonality:
Polyclonal
Specificity:
DCP1B Antibody detects endogenous levels of total DCP1B.
RRID:
AB_2845890
Cite Format: Affinity Biosciences Cat# DF12929, RRID:AB_2845890.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DCP 1B; DCP1; DCP1 decapping enzyme homolog B; DCP1B; DCP1B_HUMAN; Decapping enzyme Dcp1b; Decapping enzyme hDcp1b; Decapping enzyme homolog B (S. cerevisiae); Decapping mRNA 1B; hDcp1b; mRNA decapping enzyme 1B; mRNA-decapping enzyme 1B;

Immunogens

Immunogen:
Uniprot:

Q8IZD4(DCP1B_HUMAN) >>Visit HPA database.

Gene(ID):
DCP1B(196513)
Sequence:
MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLFVYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQNLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTGSSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQPTSVPPKERESGLLPVGGQEPPAAATSLLLPIQSPEPSVITSSPLTKLQLQEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKKTM

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
83
Pig
58
Dog
58
Bovine
56
Sheep
56
Rabbit
55
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8IZD4 As Substrate

Site PTM Type Enzyme
A2 Acetylation
K12 Ubiquitination
S67 Phosphorylation
K69 Ubiquitination
K89 Ubiquitination
Y110 Phosphorylation
K128 Ubiquitination
Y133 Phosphorylation
K137 Ubiquitination
T142 Phosphorylation
S147 Phosphorylation
K157 Ubiquitination
Y172 Phosphorylation
T173 Phosphorylation
K183 Ubiquitination
S186 Phosphorylation
S187 Phosphorylation
S188 Phosphorylation
Y191 Phosphorylation
K198 Ubiquitination
S227 Phosphorylation
T229 Phosphorylation
K234 Ubiquitination
S275 Phosphorylation
Y276 Phosphorylation
S283 Phosphorylation
S336 Phosphorylation
K358 Ubiquitination
T362 Phosphorylation
S372 Phosphorylation
T373 Phosphorylation
S385 Phosphorylation
T392 Phosphorylation
S448 Phosphorylation
K455 Ubiquitination
K488 Ubiquitination
T504 Phosphorylation
S511 Phosphorylation
S566 Phosphorylation

Research Backgrounds

Function:

May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).

Subcellular Location:

Cytoplasm. Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Binds DCP1A. Part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 and CNOT6.

Family&Domains:

Belongs to the DCP1 family.

Research Fields

· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.

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