COSMC Antibody | Affinity Biosciences

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Western blot analysis of extracts from HepG2 cells, using COSMC Antibody.

Western blot analysis of extracts from Mouse spleen, using COSMC Antibody.

Product:	COSMC Antibody
Catalog:	DF12911
Description:	Rabbit polyclonal antibody to COSMC
Application:	WB
Reactivity:	Human, Mouse, Rat
Prediction:	Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.:	37 kDa; 36kD(Calculated).
Uniprot:	Q96EU7
RRID:	AB_2845872

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Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

Size	Price	Inventory
100ul	$280	In stock
200ul	$350	In stock

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Related Downloads

MS Report

HPLC Report

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human,Mouse,Rat

Prediction:

Pig(92%), Bovine(92%), Horse(92%), Sheep(92%), Rabbit(83%), Dog(92%), Chicken(83%), Xenopus(92%)

Clonality:

Polyclonal

Specificity:

COSMC Antibody detects endogenous levels of total COSMC.

RRID:

AB_2845872
Cite Format: Affinity Biosciences Cat# DF12911, RRID:AB_2845872.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

;HSPC067; 3-galactosyltransferase 2; Beta 1,3 galactosyltransferase 2; Beta1,3 galactosyltransferase 2; C1Gal T2; C1Gal-T2; C1GALT1 specific chaperone 1; C1GALT1-specific chaperone 1; C1galt1c1; C1GalT2; C1GLC_HUMAN; C38H2 L1; C38H2 like protein 1; C38H2-L1; C38H2-like protein 1; C38H2L1; Core 1 beta1; Core 1 beta3 galactosyltransferase specific molecular chaperone; Core 1 beta3-Gal-T2; Core 1 beta3-galactosyltransferase-specific molecular chaperone; Core 1 UDP galactose:N acetylgalactosamine alpha R beta 1,3 galactosyltransferase 2; COSMC; MGC19947; MST143;

Immunogens

Immunogen:

Uniprot:

Q96EU7(C1GLC_HUMAN) >>Visit HPA database.

Gene(ID):

C1GALT1C1(29071)

Expression:

Q96EU7 C1GLC_HUMAN:

Ubiquitously expressed. Abundantly expressed in salivary gland, stomach, small intestine, kidney, and testis and at intermediate levels in whole brain, cerebellum, spinal cord, thymus, spleen, trachea, lung, pancreas, ovary, and uterus.

Sequence:

Q96EU7 C1GLC_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MLSESSSFLKGVMLGSIFCALITMLGHIRIGHGNRMHHHEHHHLQAPNKEDILKISEDERMELSKSFRVYCIILVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINMDTNDMWLMMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTIKSGDLEYVGMEGGIVLSVESMKRLNSLLNIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDADGKDVFNTKSVGLSIKEAMTYHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFGHIFNDALVFLPPNGSDND

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species

Results

Score

Pig

Horse

Bovine

Sheep

Dog

Xenopus

Chicken

Rabbit

Zebrafish

Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96EU7 As Substrate

Q96EU7

Site	PTM Type	Source
K54	Ubiquitination	Uniprot
S81	Phosphorylation	Uniprot
K92	Ubiquitination	Uniprot
K96	Ubiquitination	Uniprot
K127	Ubiquitination	Uniprot
K161	Ubiquitination	Uniprot
K206	Ubiquitination	Uniprot
K216	Ubiquitination	Uniprot
K221	Ubiquitination	Uniprot
K243	Ubiquitination	Uniprot
K249	Ubiquitination	Uniprot

Research Backgrounds

Q96EU7_C1GLC_HUMAN

Function:

Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).

Subcellular Location:

Membrane>Single-pass type II membrane protein.

Tissue Specificity:

Subunit Structure:

Associates with core 1 beta-3-galactosyltransferase (C1GALT1), probably not with the soluble active form.

Family&Domains:

Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.

Research Fields

· Metabolism > Glycan biosynthesis and metabolism > Mucin type O-glycan biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

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COSMC Antibody - #DF12911