Product: COQ5 Antibody
Catalog: DF12910
Description: Rabbit polyclonal antibody to COQ5
Application: WB
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 37 kDa, 30 kDa; 37kD(Calculated).
Uniprot: Q5HYK3
RRID: AB_2845871

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 100ul $280 In stock
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Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(92%), Bovine(83%), Horse(92%), Sheep(83%), Rabbit(83%), Dog(92%)
Clonality:
Polyclonal
Specificity:
COQ5 Antibody detects endogenous levels of total COQ5.
RRID:
AB_2845871
Cite Format: Affinity Biosciences Cat# DF12910, RRID:AB_2845871.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

2-methoxy-6-polyprenyl-1; 4-benzoquinol methylase; COQ5; COQ5_HUMAN; mitochondrial; Ubiquinone biosynthesis methyltransferase COQ5; Ubiquinone biosynthesis methyltransferase COQ5, mitochondrial;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q5HYK3 COQ5_HUMAN:

Widely expressed, with highest levels in liver, lung, placenta and skeletal muscle.

Sequence:
MAAPGSCALWSYCGRGWSRAMRGCQLLGLRSSWPGDLLSARLLSQEKRAAETHFGFETVSEEEKGGKVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQHQRKQKRQLRAQQNLSWEEIAKEYQNEEDSLGGSRVVVCDINKEMLKVGKQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVAIHSGFKL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
92
Horse
92
Dog
92
Bovine
83
Sheep
83
Rabbit
83
Chicken
75
Xenopus
58
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q5HYK3 As Substrate

Site PTM Type Enzyme
T58 Phosphorylation
S60 Phosphorylation
Y69 Phosphorylation
K95 Ubiquitination
Y283 Phosphorylation

Research Backgrounds

Function:

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

Subcellular Location:

Mitochondrion inner membrane>Peripheral membrane protein>Matrix side.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed, with highest levels in liver, lung, placenta and skeletal muscle.

Subunit Structure:

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.

Family&Domains:

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.

Research Fields

· Metabolism > Metabolism of cofactors and vitamins > Ubiquinone and other terpenoid-quinone biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

Restrictive clause

 

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