C14orf39 Antibody - #DF12863

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Product: C14orf39 Antibody
Catalog: DF12863
Description: Rabbit polyclonal antibody to C14orf39
Application: WB IHC
Reactivity: Human, Mouse
Mol.Wt.: 50 kDa; 68kD(Calculated).
Uniprot: Q8N1H7
RRID: AB_2845824

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
C14orf39 Antibody detects endogenous levels of total C14orf39.
RRID:
AB_2845824
Cite Format: Affinity Biosciences Cat# DF12863, RRID:AB_2845824.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

C14orf39; Chromosome 14 open reading frame 39; Protein SIX6OS1; S6OS1_HUMAN; Six6 opposite strand transcript 1; Six6os1;

Immunogens

Immunogen:
Uniprot:

Q8N1H7(S6OS1_HUMAN) >>Visit HPA database.

Gene(ID):
SIX6OS1(317761)
Expression:
Q8N1H7 S6OS1_HUMAN:

Highest expression in retina, skeletal muscle and colon.

Sequence:
MNDSLFVSLDRLLLEFVFQYEQDISTKEEMIQRINKCCEDIKENKVTICRIHETINATDEEIDHYCKHSEEIKDNCRNWKPTCDVFRKHEDYMQDQFTVYQGTVEKDKEMYHDYICQYKEVLKQYQLKYSETPFSREYYEKKREHEEIQSRVLACTEQLKMNETIFMKFRVPAPFPSLTKWTLNIVNLRCETQDILKHASNLTKSSSELKKEVDEMEIEINYLNQQISRHNETKALSETLEEKNKNTENRKELKERIFGKDEHVLTLNKTQSSQLFLPYESQKLVRPIKMHSSEPRVADIKEESSAKQSKLANIDFRQKENDTQIFNDSAVDNHSKCSHITTITSSQKFMQVRLLTPQKQSNSNQWSEKGDKDAEYGDKGTVRQVRESKCTSQAIYTEHFGKSVENDSDEVEERAENFPRTSEIPIFLGTPKAVKAPESLEKIKFPKTPPFEINRNRNAVPEVQTEKESPGLSFLMSYTSRSPGLNLFDSSVFDTEISSDQFNEHYSARNLNPLSSEQEIGNLLEKPEGEDGFTFSFPSDTSTHTFGAGKDDFSFPFSFGQGQNSIPSSSLKGFSSSSQNTTQFTFF

PTMs - Q8N1H7 As Substrate

Site PTM Type Enzyme
K80 Ubiquitination
Y129 Phosphorylation
Y139 Phosphorylation
T247 Phosphorylation
K283 Acetylation
T465 Phosphorylation

Research Backgrounds

Function:

Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination. Required for the appropriate processing of intermediate recombination nodules before crossover formation.

Subcellular Location:

Chromosome.
Note: Component of the central element of the synaptonemal complex. In spermatocytes, detected from zygonema to pachynema and localizes along synapsed lateral elements. Loading to the central element of the synaptonemal complex is dependent on the assembly of the tripartite synaptonemal complex structure that occurs upon synapsis between homologous chromosomes.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highest expression in retina, skeletal muscle and colon.

Subunit Structure:

Interacts with SYCE1. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis (By similarity).

Restrictive clause

 

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