ABCB6 Antibody - #DF12805

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Product: ABCB6 Antibody
Catalog: DF12805
Description: Rabbit polyclonal antibody to ABCB6
Application: WB IHC
Reactivity: Human
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 84 kDa; 94kD(Calculated).
Uniprot: Q9NP58
RRID: AB_2845766

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Pig(100%), Bovine(100%), Horse(90%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(89%)
Clonality:
Polyclonal
Specificity:
ABCB6 Antibody detects endogenous levels of total ABCB6.
RRID:
AB_2845766
Cite Format: Affinity Biosciences Cat# DF12805, RRID:AB_2845766.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ABC; ABC transporter umat; ABC14; Abcb6; ABCB6_HUMAN; ATP binding cassette sub family B member 6, mitochondrial precursor; ATP binding cassette, sub family B (MDR/TAP), member 6; ATP-binding cassette half-transporter; ATP-binding cassette sub-family B member 6; ATP-binding cassette sub-family B member 6, mitochondrial; DUH3; LAN; MCOPCB7; Mitochondrial ABC transporter 3; mitochondrial; Mt ABC transporter 3; Mt-ABC transporter 3; MTABC3; P glycoprotein related protein; P-glycoprotein-related protein; PRP; Ubiquitously expressed mammalian ABC half transporter; Ubiquitously-expressed mammalian ABC half transporter; UMAT;

Immunogens

Immunogen:
Uniprot:

Q9NP58(ABCB6_HUMAN) >>Visit HPA database.

Gene(ID):
ABCB6(10058)
Expression:
Q9NP58 ABCB6_HUMAN:

Widely expressed. High expression is detected in the retinal epithelium.

Sequence:
MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGADSLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGACGLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTMER

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Horse
90
Chicken
89
Xenopus
78
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9NP58 As Substrate

Site PTM Type Enzyme
T444 Phosphorylation
T449 Phosphorylation
S456 Phosphorylation
K464 Ubiquitination
K482 Sumoylation
K482 Ubiquitination
K569 Ubiquitination
K575 Ubiquitination
K726 Ubiquitination
K743 Ubiquitination
K771 Ubiquitination
K836 Ubiquitination

Research Backgrounds

Function:

Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.

Subcellular Location:

Cell membrane>Multi-pass membrane protein. Mitochondrion outer membrane>Multi-pass membrane protein. Endoplasmic reticulum membrane>Multi-pass membrane protein. Golgi apparatus membrane>Multi-pass membrane protein. Endosome membrane>Multi-pass membrane protein.
Note: localized to the endosome-like compartment and dendrite tips.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed. High expression is detected in the retinal epithelium.

Subunit Structure:

Homodimer.

Family&Domains:

Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.

Research Fields

· Environmental Information Processing > Membrane transport > ABC transporters.

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