TRAF5 Antibody - #DF12779
| Product: | TRAF5 Antibody |
| Catalog: | DF12779 |
| Description: | Rabbit polyclonal antibody to TRAF5 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 55 kDa; 64kD(Calculated). |
| Uniprot: | O00463 |
| RRID: | AB_2845740 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12779, RRID:AB_2845740.
Fold/Unfold
MGC:39780; RING finger protein 84; RNF 84; RNF84; TNF receptor associated factor 5; TNF receptor-associated factor 5; TRAF 5; Traf5; TRAF5_HUMAN;
Immunogens
Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
- O00463 TRAF5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O00463 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K8 | Ubiquitination | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| C161 | S-Nitrosylation | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K234 | Ubiquitination | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| K355 | Ubiquitination | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| K414 | Ubiquitination | Uniprot | |
| K493 | Ubiquitination | Uniprot | |
| K500 | Ubiquitination | Uniprot | |
| K509 | Ubiquitination | Uniprot | |
| K534 | Ubiquitination | Uniprot | |
| K539 | Ubiquitination | Uniprot |
Research Backgrounds
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
Cytoplasm. Cytoplasm>Cytosol.
Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
Homotrimer (Probable). Heteromer with TRAF3. Associates with TNFRSF5/CD40 through interaction with TRAF3. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17, TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, and TRAF and TNF receptor associated protein TDP2. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain).
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Belongs to the TNF receptor-associated factor family. A subfamily.
Research Fields
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > TNF signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
· Human Diseases > Cancers: Specific types > Small cell lung cancer. (View pathway)
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > IL-17 signaling pathway. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.