Product: TCN2 Antibody
Catalog: DF12767
Source: Rabbit
Application: WB
Reactivity: Human, Mouse, Rat
Prediction: Pig, Rabbit
Mol.Wt.: 48 kD; 48kD(Calculated).
Uniprot: P20062
RRID: AB_2845728

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Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(90%), Rabbit(100%)
Clonality:
Polyclonal
Specificity:
TCN2 Antibody detects endogenous levels of total TCN2.
RRID:
AB_2845728
Cite Format: Affinity Biosciences Cat# DF12767, RRID:AB_2845728.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

D22S676; D22S750; II; Macrocytic anemia; OTTHUMP00000199117; OTTHUMP00000199118; OTTHUMP00000199119; TC; TC II; TC II deficiency; TC-2; TC2; TCII; TCN2; TCN2 deficiency; TCO2_HUMAN; Transcobalamin 2; Transcobalamin 2 deficiency; Transcobalamin II; Transcobalamin II; macrocytic anemia; Transcobalamin-2; Vitamin B12 binding protein 2;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Sequence:
MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLLYAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHFGNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKTYIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLKKAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETIELRLVSW

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Pig
90
Bovine
78
Dog
78
Sheep
75
Horse
60
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

Research Backgrounds

Function:

Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with CD320 (via LDL-receptor class A domains).

Family&Domains:

Belongs to the eukaryotic cobalamin transport proteins family.

Research Fields

· Organismal Systems > Digestive system > Vitamin digestion and absorption.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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