Syntaxin7 Antibody - #DF12762

(2)  
Product: Syntaxin7 Antibody
Catalog: DF12762
Description: Rabbit polyclonal antibody to Syntaxin7
Application: WB IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 35 kDa; 30kD(Calculated).
Uniprot: O15400
RRID: AB_2845723

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(92%), Horse(100%), Sheep(92%), Rabbit(100%), Dog(100%), Chicken(83%)
Clonality:
Polyclonal
Specificity:
Syntaxin7 Antibody detects endogenous levels of total Syntaxin7.
RRID:
AB_2845723
Cite Format: Affinity Biosciences Cat# DF12762, RRID:AB_2845723.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

STX7; STX7_HUMAN; Syn7; Syntaxin-7;

Immunogens

Immunogen:
Uniprot:

O15400(STX7_HUMAN) >>Visit HPA database.

Gene(ID):
STX7(8417)
Expression:
O15400 STX7_HUMAN:

Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.

Sequence:
MSYTPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKVQRQAAEREKEFVARVRASSRVSGSFPEDSSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTLCIIILILVIGVAIISLIIWGLNH

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Dog
100
Rabbit
100
Bovine
92
Sheep
92
Chicken
83
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O15400 As Substrate

Site PTM Type Enzyme
S2 Acetylation
S2 Phosphorylation
Y3 Phosphorylation
T4 Phosphorylation
K24 Ubiquitination
C28 S-Nitrosylation
T41 Phosphorylation
S45 Phosphorylation
K55 Ubiquitination
K71 Ubiquitination
S75 Phosphorylation
T78 Phosphorylation
T79 Phosphorylation
S81 Phosphorylation
K87 Acetylation
K90 Acetylation
K106 Ubiquitination
S125 Phosphorylation
S126 Phosphorylation
S129 Phosphorylation
S131 Phosphorylation
S136 Phosphorylation
K138 Ubiquitination
S144 Phosphorylation
T149 Phosphorylation
T161 Phosphorylation
S173 Phosphorylation
S205 Phosphorylation

Research Backgrounds

Function:

May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

Subcellular Location:

Early endosome membrane>Single-pass type IV membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.

Subunit Structure:

Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A.

Family&Domains:

Belongs to the syntaxin family.

Research Fields

· Cellular Processes > Transport and catabolism > Phagosome.   (View pathway)

· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.

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