SDPR Antibody - #DF12733
| Product: | SDPR Antibody |
| Catalog: | DF12733 |
| Description: | Rabbit polyclonal antibody to SDPR |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 70 kDa; 47kD(Calculated). |
| Uniprot: | O95810 |
| RRID: | AB_2845694 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12733, RRID:AB_2845694.
Fold/Unfold
Cavin 2; Cavin-2; Phosphatidylserine binding protein; Phosphatidylserine-binding protein; PS p68; PS-p68; Sdpr; SDPR_HUMAN; SDR; Serum deprivation response; Serum deprivation response protein; Serum deprivation-response protein;
Immunogens
Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
- O95810 CAVN2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGEDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGDPVQPAVLQVHQTS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95810 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K10 | Ubiquitination | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| T33 | Phosphorylation | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K99 | Ubiquitination | Uniprot | |
| S101 | Phosphorylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| Y103 | Phosphorylation | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| S192 | Phosphorylation | Uniprot | |
| T196 | Phosphorylation | Uniprot | |
| T199 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| S204 | Phosphorylation | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| S247 | Phosphorylation | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| T260 | Phosphorylation | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| S264 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| S288 | Phosphorylation | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| T296 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| T360 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S366 | Phosphorylation | Uniprot | |
| S370 | Phosphorylation | Uniprot | |
| Y395 | Phosphorylation | Uniprot | |
| S398 | Phosphorylation | Uniprot | |
| Y399 | Phosphorylation | Uniprot | |
| S403 | Phosphorylation | Uniprot | |
| S409 | Phosphorylation | Uniprot |
Research Backgrounds
Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).
Phosphorylated on Ser residues.
Cytoplasm>Cytosol. Membrane>Caveola.
Note: Localizes in the caveolae in a caveolin-dependent manner.
Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with CAVIN4; this augments the transactivation of NPPA by CAVIN4. Interacts with CAVIN1. Interacts with CAV3.
The leucine-zipper domain is essential for its localization in the caveolae.
Belongs to the CAVIN family.
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