RNASEH2C Antibody - #DF12725

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Product: RNASEH2C Antibody
Catalog: DF12725
Description: Rabbit polyclonal antibody to RNASEH2C
Application: WB IHC IF/ICC
Reactivity: Human
Mol.Wt.: 22 kDa; 18kD(Calculated).
Uniprot: Q8TDP1
RRID: AB_2845686

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
RNASEH2C Antibody detects endogenous levels of total RNASEH2C.
RRID:
AB_2845686
Cite Format: Affinity Biosciences Cat# DF12725, RRID:AB_2845686.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

AGS3; Aicardi-Goutieres syndrome 3 protein; AYP1; Ribonuclease H2 subunit C; Ribonuclease HI subunit C; RNase H1 small subunit; RNASEH2C; RNH2C;

Immunogens

Immunogen:
Uniprot:

Q8TDP1(RNH2C_HUMAN) >>Visit HPA database.

Gene(ID):
RNASEH2C(84153)
Expression:
Q8TDP1 RNH2C_HUMAN:

Widely expressed.

Sequence:
MESGDEAAIERHRVHLRSATLRDAVPATLHLLPCEVAVDGPAPVGRFFTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTEEKKVSMGKPDPLRDSGTDDQEEEPLERDFDRFIGATANFSRFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQVPED

PTMs - Q8TDP1 As Substrate

Site PTM Type Enzyme
M1 Acetylation
S3 Phosphorylation
S62 Phosphorylation
R64 Methylation
S92 Phosphorylation
S102 Phosphorylation
R114 Methylation
K143 Sumoylation
K143 Ubiquitination

Research Backgrounds

Function:

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed.

Subunit Structure:

The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

Family&Domains:

Belongs to the RNase H2 subunit C family.

Research Fields

· Genetic Information Processing > Replication and repair > DNA replication.

Restrictive clause

 

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For Research Use Only.
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