PPARGC1B Antibody - #DF12703
| Product: | PPARGC1B Antibody |
| Catalog: | DF12703 |
| Description: | Rabbit polyclonal antibody to PPARGC1B |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 110 kDa; 113kD(Calculated). |
| Uniprot: | Q86YN6 |
| RRID: | AB_2845664 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12703, RRID:AB_2845664.
Fold/Unfold
Peroxisome proliferator-activated receptor gamma coactivator 1-beta;PGC-1-beta;PPAR-gamma coactivator 1-beta;PPARGC-1-beta;PGC-1-related estrogen receptor alpha coactivator;PERC;PGC1;PGC1B;PPARGC1;
Immunogens
- Q86YN6 PRGC2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFPELDLSQLDASDFDSATCFGELQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPRDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q86YN6 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S239 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| K303 | Ubiquitination | Uniprot | |
| K314 | Ubiquitination | Uniprot | |
| K357 | Ubiquitination | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| S570 | Phosphorylation | P31749 (AKT1) | Uniprot |
| S638 | Phosphorylation | Uniprot | |
| S643 | Phosphorylation | Uniprot | |
| T647 | Phosphorylation | Uniprot | |
| S711 | Phosphorylation | Uniprot | |
| S854 | Phosphorylation | Uniprot | |
| S856 | Phosphorylation | Uniprot | |
| S859 | Phosphorylation | Uniprot | |
| S865 | Phosphorylation | Uniprot | |
| Y943 | Phosphorylation | Uniprot | |
| T947 | Phosphorylation | Uniprot | |
| Y948 | Phosphorylation | Uniprot | |
| Y987 | Phosphorylation | Uniprot | |
| Y990 | Phosphorylation | Uniprot | |
| S992 | Phosphorylation | Uniprot |
Research Backgrounds
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
Nucleus.
Ubiquitous with higher expression in heart, brain and skeletal muscle.
Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with estrogen receptor alpha/ESR1.
Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
Research Fields
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
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