JAKMIP1 Antibody - #DF12647

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Product: JAKMIP1 Antibody
Catalog: DF12647
Description: Rabbit polyclonal antibody to JAKMIP1
Application: WB
Reactivity: Human, Mouse
Prediction: Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken
Mol.Wt.: 73 kDa; 73kD(Calculated).
Uniprot: Q96N16
RRID: AB_2845609

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(92%), Zebrafish(100%), Bovine(92%), Horse(92%), Sheep(92%), Dog(92%), Chicken(83%)
Clonality:
Polyclonal
Specificity:
JAKMIP1 Antibody detects endogenous levels of total JAKMIP1.
RRID:
AB_2845609
Cite Format: Affinity Biosciences Cat# DF12647, RRID:AB_2845609.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FLJ31564; GABA B receptor binding protein; GABA-B receptor-binding protein; GABABRBP; Jak and microtubule interacting protein 1; JAKMIP 1; JAKMIP1; JAMIP1; Janus kinase and microtubule interacting protein 1; Janus kinase and microtubule-interacting protein 1; JKIP1_HUMAN; Marlin 1; Marlin-1; MARLIN1; Multiple alpha-helices and RNA-linker protein 1; Multiple coiled coil GABABR1 binding protein; OTTHUMP00000155144; OTTHUMP00000203209; OTTHUMP00000203210; OTTHUMP00000203212; OTTHUMP00000217225; OTTHUMP00000217781;

Immunogens

Immunogen:
Uniprot:

Q96N16(JKIP1_HUMAN) >>Visit HPA database.

Gene(ID):
JAKMIP1(152789)
Expression:
Q96N16 JKIP1_HUMAN:

Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine.

Sequence:
MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVRDSICCKLSNGADILFEPKLKFM

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Zebrafish
100
Pig
92
Horse
92
Bovine
92
Sheep
92
Dog
92
Chicken
83
Xenopus
75
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96N16 As Substrate

Site PTM Type Enzyme
S7 Phosphorylation
K73 Ubiquitination
K235 Ubiquitination
K251 Ubiquitination
K293 Ubiquitination
S376 Phosphorylation
K378 Ubiquitination
T381 Phosphorylation
S382 Phosphorylation
S387 Phosphorylation
T467 Phosphorylation
T470 Phosphorylation
K541 Ubiquitination
K546 Ubiquitination
K551 Ubiquitination
K556 Ubiquitination
K569 Ubiquitination
K588 Ubiquitination
K610 Ubiquitination
K622 Ubiquitination

Research Backgrounds

Function:

Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.

Subcellular Location:

Cytoplasm>Cytoskeleton. Membrane>Peripheral membrane protein.
Note: Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine.

Subunit Structure:

Homodimer. Forms a complex with GABBR1 and KIF5B/kinesin-1. Interacts with JAK1 and TYK2.

Family&Domains:

Belongs to the JAKMIP family.

Restrictive clause

 

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