GGCX Antibody | Affinity Biosciences

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IF/ICC

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GGCX Antibody - Western blot analysis of extracts from MCF-7 cells, using GGCX Antibody.

GGCX Antibody - Western blot analysis of extracts from Hela cells, using GGCX Antibody.

GGCX Antibody - DF12616 staining Hela cells by IF/ICC.

Product:	GGCX Antibody
Catalog:	DF12616
Description:	Rabbit polyclonal antibody to GGCX
Application:	WB IF/ICC
Reactivity:	Human, Mouse, Rat
Prediction:	Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
Mol.Wt.:	88 kDa; 88kD(Calculated).
Uniprot:	P38435
RRID:	AB_2845578

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Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

Size	Price	Inventory
100ul	$280	In stock
200ul	$350	In stock

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Related Downloads

MS Report

HPLC Report

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human,Mouse,Rat

Prediction:

Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(100%)

Clonality:

Polyclonal

Specificity:

GGCX Antibody detects endogenous levels of total GGCX.

RRID:

AB_2845578
Cite Format: Affinity Biosciences Cat# DF12616, RRID:AB_2845578.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

FLJ26629; Gamma glutamyl carboxylase; Gamma-glutamyl carboxylase; GC; GGCX; Peptidyl glutamate 4 carboxylase; Peptidyl-glutamate 4-carboxylase; Vitamin K dependent gamma carboxylase; Vitamin K gamma glutamyl carboxylase; Vitamin K-dependent gamma-carboxylase; VKCFD 1; VKCFD1; VKGC_HUMAN;

Immunogens

Immunogen:

Uniprot:

P38435(VKGC_HUMAN) >>Visit HPA database.

Gene(ID):

GGCX(2677)

Sequence:

P38435 VKGC_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLLNAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYKRSRGKSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species

Results

Score

Pig

100

Horse

100

Bovine

100

Sheep

100

Dog

100

Xenopus

100

Rabbit

100

Zebrafish

Chicken

Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P38435 As Substrate

P38435

Site	PTM Type	Source
A2	Acetylation	Uniprot
S7	Phosphorylation	Uniprot
T10	Phosphorylation	Uniprot
S11	Phosphorylation	Uniprot
K16	Ubiquitination	Uniprot
K19	Acetylation	Uniprot
K19	Ubiquitination	Uniprot
K21	Ubiquitination	Uniprot
S26	Phosphorylation	Uniprot
K91	Ubiquitination	Uniprot
K318	Ubiquitination	Uniprot
K334	Ubiquitination	Uniprot
K346	Ubiquitination	Uniprot
K351	Ubiquitination	Uniprot
K438	Ubiquitination	Uniprot
K445	Ubiquitination	Uniprot
N459	N-Glycosylation	Uniprot
K515	Ubiquitination	Uniprot
N550	N-Glycosylation	Uniprot
K578	Ubiquitination	Uniprot
S695	Phosphorylation	Uniprot

Research Backgrounds

P38435_VKGC_HUMAN

Function:

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.

Subcellular Location:

Endoplasmic reticulum membrane>Multi-pass membrane protein.

Subunit Structure:

Monomer. May interact with CALU (By similarity).

Family&Domains:

Belongs to the vitamin K-dependent gamma-carboxylase family.

Research Fields

· Metabolism > Metabolism of cofactors and vitamins > Ubiquinone and other terpenoid-quinone biosynthesis.

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GGCX Antibody - #DF12616