FATP4 Antibody - #DF12606

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Product: FATP4 Antibody
Catalog: DF12606
Description: Rabbit polyclonal antibody to FATP4
Application: WB
Reactivity: Human
Prediction: Zebrafish, Bovine, Horse, Rabbit, Dog, Xenopus
Mol.Wt.: 70 kDa; 72kD(Calculated).
Uniprot: Q6P1M0
RRID: AB_2845568

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Zebrafish(82%), Bovine(92%), Horse(92%), Rabbit(100%), Dog(92%), Xenopus(82%)
Clonality:
Polyclonal
Specificity:
FATP4 Antibody detects endogenous levels of total FATP4.
RRID:
AB_2845568
Cite Format: Affinity Biosciences Cat# DF12606, RRID:AB_2845568.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ACSVL 4; ACSVL4; EC 6.2.1; FATP 4; FATP4; Fatty acid transport protein 4; Fatty acid transport protein4; IPS; Long chain fatty acid transport protein 4; Long chain fatty acid transport protein4; OTTHUMP00000022264; S27A4; SLC27 A4; SLC27A 4; Solute carrier family 27 (fatty acid transporter) member 4; Solute carrier family 27 member 4; Solute carrier family 27 member4;

Immunogens

Immunogen:
Uniprot:

Q6P1M0(S27A4_HUMAN) >>Visit HPA database.

Gene(ID):
SLC27A4(10999)
Expression:
Q6P1M0 S27A4_HUMAN:

Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue.

Sequence:
MLLGASLVGVLLFSKLVLKLPWTQVGFSLLFLYLGSGGWRFIRVFIKTIRRDIFGGLVLLKVKAKVRQCLQERRTVPILFASTVRRHPDKTALIFEGTDTHWTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASLDPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLNQGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVASPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Horse
92
Bovine
92
Dog
92
Xenopus
82
Zebrafish
82
Chicken
73
Pig
0
Sheep
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q6P1M0 As Substrate

Site PTM Type Enzyme
S6 Phosphorylation
T75 Phosphorylation
S82 Phosphorylation
K90 Ubiquitination
T170 Phosphorylation
K227 Ubiquitination
K235 Ubiquitination
Y243 Phosphorylation
Y245 Phosphorylation
Y263 Phosphorylation
Y264 Phosphorylation
S373 Phosphorylation
S411 Phosphorylation
T425 Phosphorylation
K454 Ubiquitination
Y463 Phosphorylation
K471 Acetylation
K471 Ubiquitination
K475 Ubiquitination
K512 Ubiquitination
S555 Phosphorylation
K571 Ubiquitination
Y576 Phosphorylation
K595 Ubiquitination
K598 Ubiquitination
K603 Ubiquitination
K612 Ubiquitination
K622 Ubiquitination
K642 Ubiquitination

Research Backgrounds

Function:

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).

Subcellular Location:

Membrane>Multi-pass membrane protein. Endoplasmic reticulum membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue.

Family&Domains:

Belongs to the ATP-dependent AMP-binding enzyme family.

Research Fields

· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.

· Organismal Systems > Endocrine system > PPAR signaling pathway.

· Organismal Systems > Digestive system > Fat digestion and absorption.

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