RASSF10 Antibody - #DF12521
| Product: | RASSF10 Antibody |
| Catalog: | DF12521 |
| Description: | Rabbit polyclonal antibody to RASSF10 |
| Application: | WB |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Sheep, Rabbit, Chicken, Xenopus |
| Mol.Wt.: | 57 kDa; 57kD(Calculated). |
| Uniprot: | A6NK89 |
| RRID: | AB_2845483 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12521, RRID:AB_2845483.
Fold/Unfold
4632411J06Rik; Ras association (RalGDS/AF 6) domain family (N terminal) member 10; Ras association (RalGDS/AF-6) domain family (N-terminal) member 10; ras association domain containing protein 10; Ras association domain-containing protein 10; RASFA_HUMAN; RASSF10;
Immunogens
Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas.
- A6NK89 RASFA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRRRQRRSRRLGSAGDPHGPGELPEPPNEDDEDDDEALPQGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWAAWGEEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTLHTLELTVAPDGAPGSGSPSREPGPQACADMWVDQARGLAKSGPGNDEDSDTGLSSMHSQDSDSLPMCESLV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - A6NK89 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T27 | Phosphorylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S212 | Phosphorylation | Uniprot |
Research Backgrounds
Plays an important role in regulating embryonic neurogenesis.
Cytoplasm>Cytosol. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Spindle pole.
Note: During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm.
Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas.
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