DIO1 Antibody - #DF12382
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12382, RRID:AB_2845187.
Fold/Unfold
5DI; deiodinase iodothyronine type I; DIO1; DIOI; IOD1_HUMAN; thyroxine deiodinase type I (selenoprotein); TXDI1; Type 1 DI; type I 5' deiodinase; Type I iodothyronine deiodinase; Type-I 5''-deiodinase;
Immunogens
A synthesized peptide derived from human DIO1, corresponding to a region within C-terminal amino acids.
- P49895 IOD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEVRAVLEKLHS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P49895 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S57 | Phosphorylation | Uniprot |
Research Backgrounds
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
Endoplasmic reticulum membrane>Single-pass membrane protein.
Belongs to the iodothyronine deiodinase family.
Research Fields
· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway. (View pathway)
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