ARHGDIB Antibody - #DF12349

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Product: ARHGDIB Antibody
Catalog: DF12349
Description: Rabbit polyclonal antibody to ARHGDIB
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 27 kDa; 23kD(Calculated).
Uniprot: P52566
RRID: AB_2845154

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(83%), Xenopus(83%)
Clonality:
Polyclonal
Specificity:
ARHGDIB Antibody detects endogenous levels of total ARHGDIB.
RRID:
AB_2845154
Cite Format: Affinity Biosciences Cat# DF12349, RRID:AB_2845154.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Arhgdib; D4; D4 GDP dissociation inhibitor; GDIA 2; GDIA2; GDID 4; GDID4; GDIR2_HUMAN; GDP dissociation inhibitor D4; LY GDI; Ly-GDI; LYGDI; MGC108926; RAP1GN1; Rho GDI 2; Rho GDI beta; Rho GDI2; Rho GDP dissociation inhibitor (GDI) beta; Rho GDP dissociation inhibitor 2; Rho GDP dissociation inhibitor beta; Rho GDP-dissociation inhibitor 2; Rho-GDI beta; RhoGDI2;

Immunogens

Immunogen:
Uniprot:

P52566(GDIR2_HUMAN) >>Visit HPA database.

Gene(ID):
ARHGDIB(397)
Expression:
P52566 GDIR2_HUMAN:

Detected in bone marrow, thymus and spleen.

Sequence:
MTEKAPEPHVEEDDDDELDSKLNYKPPPQKSLKELQEMDKDDESLIKYKKTLLGDGPVVTDPKAPNVVVTRLTLVCESAPGPITMDLTGDLEALKKETIVLKEGSEYRVKIHFKVNRDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDDDKQDHLSWEWNLSIKKEWTE

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
83
Chicken
83
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P52566 As Substrate

Site PTM Type Enzyme
K4 Acetylation
K4 Ubiquitination
S20 Phosphorylation
K21 Acetylation
K21 Ubiquitination
Y24 Phosphorylation P12931 (SRC) , P43405 (SYK)
K25 Acetylation
K25 Ubiquitination
K30 Acetylation
K30 Ubiquitination
S31 Phosphorylation P17252 (PRKCA)
K33 Acetylation
K33 Ubiquitination
K40 Acetylation
K40 Ubiquitination
S44 Phosphorylation
K47 Acetylation
K47 Ubiquitination
Y48 Phosphorylation
K50 Ubiquitination
T51 Phosphorylation
T60 Phosphorylation
K63 Acetylation
K63 Ubiquitination
C76 S-Nitrosylation
S78 Phosphorylation
K95 Acetylation
K95 Ubiquitination
K96 Ubiquitination
K102 Acetylation
K102 Ubiquitination
K110 Ubiquitination
K114 Ubiquitination
K124 Acetylation
K124 Ubiquitination
Y130 Phosphorylation
K135 Acetylation
K135 Ubiquitination
K138 Acetylation
K138 Ubiquitination
S145 Phosphorylation
Y146 Phosphorylation
Y153 Phosphorylation P12931 (SRC)
T157 Phosphorylation
K164 Ubiquitination
K175 Acetylation
K175 Ubiquitination
T179 Phosphorylation
S194 Phosphorylation
K197 Acetylation

Research Backgrounds

Function:

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members.

Subcellular Location:

Cytoplasm>Cytosol.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Detected in bone marrow, thymus and spleen.

Subunit Structure:

Interacts with RHOA. Interacts with RAC1. Interacts with RAC2. Interacts with CDC42.

Family&Domains:

Belongs to the Rho GDI family.

Research Fields

· Organismal Systems > Nervous system > Neurotrophin signaling pathway.   (View pathway)

· Organismal Systems > Excretory system > Vasopressin-regulated water reabsorption.

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