MTHFD2 Antibody - #DF12213
| Product: | MTHFD2 Antibody |
| Catalog: | DF12213 |
| Description: | Rabbit polyclonal antibody to MTHFD2 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 38 kDa; 38kD(Calculated). |
| Uniprot: | P13995 |
| RRID: | AB_2845018 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12213, RRID:AB_2845018.
Fold/Unfold
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Descriptions; Methenyltetrahydrofolate cyclohydrolase; methylene tetrahydrofolate dehydrogenase (NAD+ dependent); methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2; methylenetetrahydrofolate dehydrogenase (NADP+ dependent); methylenetetrahydrofolate dehydrogenase 2; MGC82516; MTDC_HUMAN; MTHFD2; mthfd2 methylene tetrahydrofolate dehydrogenase (NAD+ dependent); NAD-dependent methylene tetrahydrofolate dehydrogenase; NAD-dependent methylenetetrahydrofolate dehydrogenase; NMDMC;
Immunogens
- P13995 MTDC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P13995 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K50 | Acetylation | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| R143 | Methylation | Uniprot | |
| S149 | Phosphorylation | Uniprot | |
| K152 | Acetylation | Uniprot | |
| K152 | Ubiquitination | Uniprot | |
| T187 | Phosphorylation | Uniprot | |
| T191 | Phosphorylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K237 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| T306 | Phosphorylation | Uniprot | |
| T324 | Phosphorylation | Uniprot | |
| K329 | Acetylation | Uniprot | |
| K343 | Ubiquitination | Uniprot |
Research Backgrounds
Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.
Mitochondrion.
Homodimer.
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Research Fields
· Metabolism > Metabolism of cofactors and vitamins > One carbon pool by folate.
· Metabolism > Global and overview maps > Metabolic pathways.
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