MAT1A Antibody - #DF12210
| Product: | MAT1A Antibody |
| Catalog: | DF12210 |
| Description: | Rabbit polyclonal antibody to MAT1A |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 44-55 kDa; 44kD(Calculated). |
| Uniprot: | Q00266 |
| RRID: | AB_2845015 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12210, RRID:AB_2845015.
Fold/Unfold
AdoMet; AdoMet synthetase 1; AI046368; Ams; MAT; MAT I/III; MATA1; Methionine adenosyltransferase 1; Methionine adenosyltransferase I, alpha; Methionine adenosyltransferase I/III; MGC108563; S adenosylmethionine synthetase isoform type 1; SADE; SAMS; SAMS1;
Immunogens
- Q00266 METK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q00266 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S73 | Phosphorylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| R264 | Methylation | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| K303 | Ubiquitination | Uniprot | |
| T341 | Phosphorylation | Uniprot | |
| K351 | Ubiquitination | Uniprot |
Research Backgrounds
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
S-nitrosylation of Cys-120 inactivates the enzyme.
An intrachain disulfide bond can be formed. The protein structure shows that the relevant Cys residues are in a position that would permit formation of a disulfide bond.
Expressed in liver.
Homotetramer (MAT-I); dimer of dimers. Homodimer (MAT-III) (By similarity).
Belongs to the AdoMet synthase family.
Research Fields
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
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