CPLX1 Antibody - #DF12192
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| Product: | CPLX1 Antibody |
| Catalog: | DF12192 |
| Description: | Rabbit polyclonal antibody to CPLX1 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| Mol.Wt.: | 15-20 kDa; 15kD(Calculated). |
| Uniprot: | O14810 |
| RRID: | AB_2844997 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12192, RRID:AB_2844997.
Fold/Unfold
921-S; complexin 1; Complexin I; Complexin-1; CPLX1; CPLX1_HUMAN; CPX I; CPX-I; CPX1; Synaphin 2; Synaphin-2;
Immunogens
Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
- O14810 CPLX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O14810 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K14 | Acetylation | Uniprot | |
| T95 | Phosphorylation | Uniprot | |
| S115 | Phosphorylation | Uniprot |
Research Backgrounds
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
Cytoplasm>Cytosol. Perikaryon. Cell junction>Synapse>Presynapse.
Note: Enriched at synaptic-releasing sites in mature neurons.
Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
Belongs to the complexin/synaphin family.
Research Fields
· Organismal Systems > Nervous system > Synaptic vesicle cycle.
References
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