RNH1 Antibody - #DF12170
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12170, RRID:AB_2844975.
Fold/Unfold
AW546468; C80305; MGC18200; MGC4569; MGC54054; OTTHUMP00000147628; OTTHUMP00000229864; OTTHUMP00000229865; OTTHUMP00000229866; OTTHUMP00000229870; OTTHUMP00000229871; OTTHUMP00000229872; Placental ribonuclease inhibitor; Placental RNase inhibitor; PRI; RAI; RI; Ribonuclease inhibitor; Ribonuclease/angiogenin inhibitor 1; Ribonuclease/angiogenin inhibitor; RINI_HUMAN; RNase inhibitor; RNH 1; RNH; RNH1; Rnh1 ribonuclease/angiogenin inhibitor 1;
Immunogens
- P13489 RINI_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P13489 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| C38 | S-Nitrosylation | Uniprot | |
| K46 | Ubiquitination | Uniprot | |
| C75 | S-Nitrosylation | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| C85 | S-Nitrosylation | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| T98 | Phosphorylation | Uniprot | |
| K169 | Acetylation | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| K226 | Ubiquitination | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| C248 | S-Nitrosylation | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| C409 | S-Nitrosylation | Uniprot | |
| K452 | Ubiquitination | Uniprot | |
| K454 | Ubiquitination | Uniprot |
Research Backgrounds
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
The N-terminus is blocked.
At least 30 of the 32 cysteine residues are in the reduced form.
Cytoplasm.
Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.
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